Evidence map›Paper›PMID 29552453›Full record

ArticleCurrent hepatology reports2018

The assessment and management of pain in cirrhosis.

Matthew Klinge, Tami Coppler, Jane M Liebschutz, Mohannad Dugum, Ajay Wassan, Andrea DiMartini, Shari Rogal

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Current hepatology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06062108 (Etude de la prévalence de la Douleur Chez le Patient Cirrhotique hospitalisé), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06062108 completednot on this mapstarted 2023, after this paper: background citation

Etude de la prévalence de la Douleur Chez le Patient Cirrhotique hospitalisé

TypeobservationalSponsorCentre Hospitalier Intercommunal de Toulon La Seyne sur MerRan2023 to 2025Enrolled30ConditionsCirrhosis, Hepatic Fibrosis, Pain, Acute, Pain, ChronicArmsPain evaluation
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Multidimensional experience of pain in adults with cirrhosis: A qualitative descriptive study.Canadian journal of pain = Revue canadienne de la douleur · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Metamizole-Associated Risks in Decompensated Hepatic Cirrhosis.Deutsches Arzteblatt international · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Opioid Avoidance After Liver Transplantation: The Ever-Shifting Pain Management Paradigm.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2020
    Article
  17. Article
  18. Article
  19. Palliative Care for Patients with End-Stage Liver Disease.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Matthew KlingeDivision of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh.
Tami CopplerDivision of Pharmacy, VA Pittsburgh Healthcare System.
Jane M LiebschutzDivision of General Internal Medicine, University of Pittsburgh.
Mohannad DugumDivision of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh.
Ajay WassanDepartment of Anesthesiology, University of Pittsburgh.
Andrea DiMartiniDepartment of Psychiatry, University of Pittsburgh.
Shari RogalDivision of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh.
University of Pittsburgh · USUniversity of Pittsburgh Medical Center · USVA Pittsburgh Healthcare System · US

Funding

Patient-Centered Outcomes Research (PCOR) Scholars ProgramK12HS022989 · AHRQ · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAPOOR, WISHWA N · 2014 to 2018
$3.9M
AHRQ HHS K12 HS022989
6 · The paper itself

Abstract

purpose of reviewThe treatment of pain in patients with cirrhosis is complicated by unpredictable hepatic drug metabolism and a higher risk of adverse drug reactions. We aimed to conduct a scoping review regarding pain management in cirrhosis. RECENT

findingsDespite the high prevalence of pain in patients with cirrhosis, there is little literature to guide the management of pain in this population. Complex pain syndromes and disease-specific pain etiologies exist are common in patients with cirrhosis. There are numerous contraindications and limitations when considering pharmacotherapy for analgesia in cirrhosis, specifically with non-steroidal anti-inflammatory drugs (NSAIDS) and opioid medications. Non-pharmacologic therapies for pain have not been specifically assessed in this population. SUMMARY: As with other populations, a multi-dimensional treatment approach to pain with a focus on physical, behavioral, procedural and pharmacologic treatment is recommended when caring for patients with cirrhosis and pain. However, more research is needed to evaluate opioid-sparing and non-pharmacologic analgesia in this population.

Indexed as

analgesiachronic liver diseasecirrhosispain

Identifiers

PMID29552453
PMCPMC5849403
OpenAlexW2793570277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.