ArticleBiomedical optics express2018
Investigation of tissue cellularity at the tip of the core biopsy needle with optical coherence tomography.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- AI-Assisted OCT Imaging for Core Needle Biopsy Guidance: The 1st in Humans Study.Diagnostics (Basel, Switzerland) · 2026Article
- In Vivo Time-Resolved Fluorescence Detection of Liver Cancer Supported by Machine Learning.Lasers in surgery and medicine · 2024Article
- Core Needle Biopsy Guidance Based on Tissue Morphology Assessment with AI-OCT Imaging.Diagnostics (Basel, Switzerland) · 2023Article
- Compression optical coherence elastography versus strain ultrasound elastography for breast cancer detection and differentiation: pilot study.Biomedical optics express · 2022Article
- Label-free multimodal nonlinear optical imaging of needle biopsy cores for intraoperative cancer diagnosis.Journal of biomedical optics · 2022Article
- Posterior segment findings by spectral-domain optical coherence tomography and clinical associations in active toxoplasmic retinochoroiditis.Scientific reports · 2022Observational
- Multimodal Optical Coherence Tomography for Intraoperative Evaluation of Tumor Margins and Surgical Margins in Breast-Conserving Surgery.Sovremennye tekhnologii v meditsine · 2022Article
- In vivo optical imaging-guided targeted sampling for precise diagnosis and molecular pathology.Scientific reports · 2021Article
- Intraoperative Label-Free Multimodal Nonlinear Optical Imaging for Point-of-Procedure Cancer Diagnostics.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the development and the pre-clinical testing of a new technology based on optical coherence tomography (OCT) for investigating tissue composition at the tip of the core biopsy needle. While ultrasound, computed tomography, and magnetic resonance imaging are routinely used to guide needle placement within a tumor, they still do not provide the resolution needed to investigate tissue cellularity (ratio between viable tumor and benign stroma) at the needle tip prior to taking a biopsy core. High resolution OCT imaging, however, can be used to investigate tissue morphology at the micron scale, and thus to determine if the biopsy core would likely have the expected composition. Therefore, we implemented this capability within a custom-made biopsy gun and evaluated its capability for a correct estimation of tumor tissue cellularity. A pilot study on a rabbit model of soft tissue cancer has shown the capability of this technique to provide correct evaluation of tumor tissue cellularity in over 85% of the cases. These initial results indicate the potential benefit of the OCT-based approach for improving the success of the core biopsy procedures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.