ArticleBiomedical optics express2018
Methods for detecting host genetic modifiers of tumor vascular function using dynamic near-infrared fluorescence imaging.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Dynamic multispectral NIR/SWIR forJournal of biomedical optics · 2024Article
- Multiparametric Brain Hemodynamics Imaging Using a Combined Ultrafast Ultrasound and Photoacoustic System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- From bone to nanoparticles: development of a novel generation of bone derived nanoparticles for image guided orthopedic regeneration.Biomaterials science · 2024Article
- Fluorescence Imaging Using Deep-Red Indocyanine Blue, a Complementary Partner for Near-Infrared Indocyanine Green.Chemical & biomedical imaging · 2024Article
- Dissecting Multiparametric Cerebral Hemodynamics using Integrated Ultrafast Ultrasound and Multispectral Photoacoustic Imaging.bioRxiv : the preprint server for biology · 2023Article
- Article
- Sterically Shielded Hydrophilic Analogs of Indocyanine Green.The Journal of organic chemistry · 2022Article
- Real-Time Longitudinal Evaluation of Tumor Blood Vessels Using a Compact Preclinical Fluorescence Imaging System.Biosensors · 2021Article
- Targeting tumor vascularization: promising strategies for vascular normalization.Journal of cancer research and clinical oncology · 2021Review
- A rapid dynamic in vivo near-infrared fluorescence imaging assay to track lung vascular permeability after acute radiation injury.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Localized and triggered release of oxaliplatin for the treatment of colorectal liver metastasis.Journal of Cancer · 2020Article
- Heritable modifiers of the tumor microenvironment influence nanoparticle uptake, distribution and response to photothermal therapy.Theranostics · 2020Article
- Differences in Expression of Mitochondrial Complexes Due to Genetic Variants May Alter Sensitivity to Radiation-Induced Cardiac Dysfunction.Frontiers in cardiovascular medicine · 2020Article
- Mapping Mammary Tumor Traits in the Rat.Methods in molecular biology (Clifton, N.J.) · 2019Review
- Erratum: Methods for detecting host genetic modifiers of tumor vascular function using dynamic near-infrared fluorescence imaging: errata.Biomedical optics express · 2018Article
- Genetic Modifiers of the Breast Tumor Microenvironment.Trends in cancer · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
Vascular supply is a critical component of the tumor microenvironment (TME) and is essential for tumor growth and metastasis, yet the endogenous genetic modifiers that impact vascular function in the TME are largely unknown. To identify the host TME modifiers of tumor vascular function, we combined a novel genetic mapping strategy [Consomic Xenograft Model] with near-infrared (NIR) fluorescence imaging and multiparametric analysis of pharmacokinetic modeling. To detect vascular flow, an intensified cooled camera based dynamic NIR imaging system with 785 nm laser diode based excitation was used to image the whole-body fluorescence emission of intravenously injected indocyanine green dye. Principal component analysis was used to extract the spatial segmentation information for the lungs, liver, and tumor regions-of-interest. Vascular function was then quantified by pK modeling of the imaging data, which revealed significantly altered tissue perfusion and vascular permeability that were caused by host genetic modifiers in the TME. Collectively, these data demonstrate that NIR fluorescent imaging can be used as a non-invasive means for characterizing host TME modifiers of vascular function that have been linked with tumor risk, progression, and response to therapy.
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