Evidence map›Paper›PMID 29552214›Full record

ArticleOncology letters2018

Anti-oncogenic activity of Chibby in the development of human nasopharyngeal carcinoma.

Cheng-Fu Cai, Li-Man Liu, Han-Jing Shangguan, Cun-Shan Liu, Xian-Yang Luo, Yi-Meng Li

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Cheng-Fu CaiDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Medical College, Xiamen University, Xiamen, Fujian 361003, P.R. China.
Li-Man LiuInstitute of Stem Cell and Regeneration Medicine, Institutions of Biomedical Science, Fudan University, Shanghai 200031, P.R. China.
Han-Jing ShangguanDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Medical College, Xiamen University, Xiamen, Fujian 361003, P.R. China.
Cun-Shan LiuDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Medical College, Xiamen University, Xiamen, Fujian 361003, P.R. China.
Xian-Yang LuoDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Medical College, Xiamen University, Xiamen, Fujian 361003, P.R. China.
Yi-Meng LiDepartment of Otorhinolaryngology, Affiliated Eye and ENT Hospital of Fudan University, Shanghai 200031, P.R. China.
First Affiliated Hospital of Xiamen University · CNEye & ENT Hospital of Fudan University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Wnt/β-catenin pathway serves important roles in cancer development. The expression and function of Chibby (Cby), as a direct antagonist of β-catenin, in nasopharyngeal carcinoma (NPC) has not been fully investigated. The present study revealed that the mRNA and protein expression of Cby was significantly lower in NPC tissue than in the adjacent normal tissue. Low expression of Cby was significantly associated with the tumor and the clinical staging. Furthermore, Cby overexpression inhibited the proliferation of human NPC SUNE1 cells and induced cell cycle arrest. In addition, Cby overexpression also significantly enhanced the susceptibility of SUNE1 cells to apoptosis. These results indicated that Cby might serve as an anti-oncogenic gene in the development of NPC and could represent a potential therapeutic target for the human NPC therapy.

Indexed as

apoptosiscell cycleChibbynasopharyngeal carcinomaWnt/β-catenin

Identifiers

PMID29552214
PMCPMC5840504
OpenAlexW2788981576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.