Evidence map›Paper›PMID 29552144›Full record

ArticleOncology letters2018

Post-operative unadjuvanted therapeutic xenovaccination with chicken whole embryo vaccine suppresses distant micrometastases and prolongs survival in a murine Lewis lung carcinoma model.

Jan Aleksander Kraśko, Karolina Žilionytė, Adas Darinskas, Neringa Dobrovolskienė, Agata Mlynska, Svetlana Riabceva, Iosif Zalutsky, Marina Derevyanko, Vladimir Kulchitsky, Olga Karaman and 6 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Jan Aleksander KraśkoLaboratory of Immunology, National Cancer Institute, Vilnius, Vilnius LT-08660, Lithuania.
Karolina ŽilionytėLaboratory of Immunology, National Cancer Institute, Vilnius, Vilnius LT-08660, Lithuania.
Adas DarinskasLaboratory of Immunology, National Cancer Institute, Vilnius, Vilnius LT-08660, Lithuania.
Neringa DobrovolskienėLaboratory of Immunology, National Cancer Institute, Vilnius, Vilnius LT-08660, Lithuania.
Agata MlynskaLaboratory of Immunology, National Cancer Institute, Vilnius, Vilnius LT-08660, Lithuania.
Svetlana RiabcevaDepartments of Neurophysiology and Pathology, Institute of Physiology, Minsk, Minsk BY-220072, Republic of Belarus.
Iosif ZalutskyDepartments of Neurophysiology and Pathology, Institute of Physiology, Minsk, Minsk BY-220072, Republic of Belarus.
Marina DerevyankoDepartments of Neurophysiology and Pathology, Institute of Physiology, Minsk, Minsk BY-220072, Republic of Belarus.
Vladimir KulchitskyDepartments of Neurophysiology and Pathology, Institute of Physiology, Minsk, Minsk BY-220072, Republic of Belarus.
Olga KaramanLaboratory of Oncoimmunology and Antitumour Vaccine Engineering, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Kyivs'ka 03022, Ukraine.
Natalia FedosovaLaboratory of Oncoimmunology and Antitumour Vaccine Engineering, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Kyivs'ka 03022, Ukraine.
Tatiana Vasyliyvna SymchychLaboratory of Oncoimmunology and Antitumour Vaccine Engineering, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Kyivs'ka 03022, Ukraine.
Gennady DidenkoLaboratory of Oncoimmunology and Antitumour Vaccine Engineering, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Kyivs'ka 03022, Ukraine.
Vasyl ChekhunLaboratory of Oncoimmunology and Antitumour Vaccine Engineering, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Kyivs'ka 03022, Ukraine.
Marius StriogaLaboratory of Immunology, National Cancer Institute, Vilnius, Vilnius LT-08660, Lithuania.
Vita PašukonienėLaboratory of Immunology, National Cancer Institute, Vilnius, Vilnius LT-08660, Lithuania.
National Cancer Institute · LTR.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology · UAInstitute of Physiology National Academy of Sciences of Belarus · BY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapy in the form of anticancer vaccination relies on the mobilization of the patient's immune system against specific cancer antigens. Instead of focusing on an autologous cell lysate, which is not always available in clinical practice, the present study investigates vaccines utilizing xenogeneic foetal tissue that are rich in oncofoetal antigens. Lewis lung carcinoma (LLC)-challenged C57BL/6 mice were treated with either a xenogeneic vaccine made from chicken whole embryo, or a xenogeneic vaccine made from rat embryonic brain tissue, supplemented with a

Indexed as

cytotoxic lymphocytesLewis lung carcinomametastasismicevaccinationxenogeneic

Identifiers

PMID29552144
PMCPMC5840525
OpenAlexW2792644430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.