The Beneficial Effects of Fish Oil Following Cisplatin-Induced Oxidative and Histological Damage in Liver of Rats.

Osman Ciftci, Elif Onat, Aslı Cetin

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Article in Iranian journal of pharmaceutical research : IJPR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

3 authors.

Osman CiftciDepartment of Pharmacology, Faculty of Medicine, University of Inonu, Malatya, Turkey.

Elif OnatMalatya State Hospital, Home Health Service Unit, Malatya, Turkey.

Aslı CetinDepartment of Histology and Embryology, Faculty of Medicine, University of Inonu, Malatya, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the protective effect of fish oil (FO) on cisplatin (CP) toxicity in the rat liver. Twenty-eight rats were divided equally into four groups, with the first being a control group. The second group (CP group) was given 7 mg/kg of CP and the third group (FO group) was given 1 FO softgel/rat/day for 14 days. The rats in the fourth group (CP + FO group) were treated with both CP and FO at the above doses. CP treatment caused significant oxidative damage via an increase in thiobarbituric acid reactive substances (TBARS) and reduced antioxidant defenses through a decrease in the activities of catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), and glutathione peroxidase (GPx) in rat liver tissue. Also, CP caused histopathological abnormalities, including necrosis, in the liver tissue. However, concurrent FO treatment prevented the negative oxidative and histopathological effects of CP. In conclusion, CP treatment can cause hepatotoxicity in rats, but dietary supplementation with FO can attenuate the oxidative and histological changes caused by CP. Thus, FO may be useful in preventing CP-induced hepatotoxicity in cancer patients.

Indexed as

CisplatinFish oilHepatotoxicityHistological damageOxidative damage

Identifiers

PMID29552051

PMCPMC5843304

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.