Evidence map›Paper›PMID 29552014›Full record

ArticleFrontiers in immunology2018

Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional

Jessica Da Gama Duarte, Sagun Parakh, Miles C Andrews, Katherine Woods, Anupama Pasam, Candani Tutuka, Simone Ostrouska, Jonathan M Blackburn, Andreas Behren, Jonathan Cebon

Open access · goldAbstract readClinical Trial, Phase I
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 82 citations in OpenAlex.

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  11. Neutrophil diversity and function in health and disease.Signal transduction and targeted therapy · 2024
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  19. Type I interferon-mediated tumor immunity and its role in immunotherapy.Cellular and molecular life sciences : CMLS · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Jessica Da Gama DuarteOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Sagun ParakhOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Miles C AndrewsOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Katherine WoodsOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Anupama PasamOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Candani TutukaOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Simone OstrouskaOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Jonathan M BlackburnDepartment of Integrative Biomedical Sciences and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Andreas BehrenOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Jonathan CebonOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Olivia Newton-John Cancer Wellness & Research Centre · AULa Trobe University · AULudwig Cancer Research · AUUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced melanoma. The first ICI to demonstrate clinical benefit, ipilimumab, targets cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4); however, the long-term overall survival is just 22%. More than 40 years ago intralesional (IL)

Indexed as

AdultAgedAutoantibodiesCancer VaccinesCombined Modality TherapyCTLA-4 AntigenFemaleHumansImmunotherapyIpilimumabMaleMelanomaMiddle AgedMycobacterium bovisNeoplasm MetastasisNeoplasm StagingAutoantibodiesCancer VaccinesCTLA-4 AntigenCTLA4 protein, humanIpilimumabbacillus Calmette–Guerinimmune-related adverse eventsipilimumabmelanomaprotein microarrays

Identifiers

PMID29552014
PMCPMC5840202
OpenAlexW2793519605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.