Evidence map›Paper›PMID 29552013›Full record

ArticleFrontiers in immunology2018

Differential Phagocytic Properties of CD45

Srikant Rangaraju, Syed Ali Raza, Noel Xiang'An Li, Ranjita Betarbet, Eric B Dammer, Duc Duong, James J Lah, Nicholas T Seyfried, Allan I Levey

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 136 citations in OpenAlex.

  1. Article
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  10. Retinoid-X-Receptor as a Mediator of Poststroke Recovery by Reversing Age-Associated Phenotypes of Microglia/Hematogenous Macrophages.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  11. Article
  12. Article
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  15. Article
  16. Review
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  18. Article
  19. Dynamics of CD44Scientific reports · 2024
    Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Srikant RangarajuDepartment of Neurology, Emory University, Atlanta, GA, United States.
Syed Ali RazaDepartment of Neurology, Emory University, Atlanta, GA, United States.
Noel Xiang'An LiDepartment of Chemistry, Emory University, Atlanta, GA, United States.
Ranjita BetarbetDepartment of Neurology, Emory University, Atlanta, GA, United States.
Eric B DammerDepartment of Neurology, Emory University, Atlanta, GA, United States.
Duc DuongDepartment of Biochemistry, Emory University, Atlanta, GA, United States.
James J LahDepartment of Neurology, Emory University, Atlanta, GA, United States.
Nicholas T SeyfriedDepartment of Biochemistry, Emory University, Atlanta, GA, United States.
Allan I LeveyDepartment of Neurology, Emory University, Atlanta, GA, United States.
Emory University · US

Funding

The Emory Alzheimer's Disease CenterP50AG025688 · NIA · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 2005 to 2019
$25.7M
Discovery of Novel Proteomic Targets in Alzheimer's DiseaseU01AG046161 · NIA · EMORY UNIVERSITY · PI BENNETT, DAVID ALAN, GESCHWIND, DANIEL H · 2014 to 2018
$8.4M
ENNCF - Viral Vector CoreP30NS055077 · NINDS · EMORY UNIVERSITY · PI BASSELL, GARY J · 2008 to 2018
$6.8M
Microglial and macrophage potassium channels as regulators of neuroinflammation in Alzheimer's DiseaseK08NS099474 · NINDS · EMORY UNIVERSITY · PI RANGARAJU, SRIKANT · 2016 to 2020
$943k
NIA NIH HHS P50 AG025688NIA NIH HHS U01 AG046161NINDS NIH HHS K08 NS099474NINDS NIH HHS P30 NS055077
6 · The paper itself

Abstract

In the central nervous system (CNS), microglia are innate immune mononuclear phagocytes (CNS MPs) that can phagocytose infectious particles, apoptotic cells, neurons, and pathological protein aggregates, such as Aβ in Alzheimer's disease (AD). While CD11b

Indexed as

PhagocytosisAgingAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainCell LineDisease Models, AnimalHumansLeukocyte Common AntigensMembrane GlycoproteinsMiceMice, Inbred C57BLMice, Mutant StrainsMicrogliaMononuclear Phagocyte SystemAmyloid beta-PeptidesLeukocyte Common AntigensMembrane GlycoproteinsReceptors, ImmunologicTrem2 protein, mouseAlzheimer’s diseaseCNS mononuclear phagocytesflow cytometryneuroinflammationphagocytosis

Identifiers

PMID29552013
PMCPMC5840283
OpenAlexW2792377614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.