ArticleFrontiers in physiology2018
High Spatial Resolution Multi-Organ Finite Element Modeling of Ventricular-Arterial Coupling.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Simulating impaired left ventricular-arterial coupling in aging and disease: a systematic review.Biomedical engineering online · 2024Pooled it
- Article
- A Modular Framework for Implicit 3D-0D Coupling in Cardiac Mechanics.Computer methods in applied mechanics and engineering · 2024Article
- Role of tissue biomechanics in the formation and function of myocardial trabeculae in zebrafish embryos.The Journal of physiology · 2024Article
- Effects of myocardial sheetlet sliding on left ventricular function.Biomechanics and modeling in mechanobiology · 2023Article
- A fast computational model for circulatory dynamics: effects of left ventricle-aorta coupling.Biomechanics and modeling in mechanobiology · 2023Article
- The dependency of fetal left ventricular biomechanics function on myocardium helix angle configuration.Biomechanics and modeling in mechanobiology · 2023Article
- Computational analysis of ventricular mechanics in hypertrophic cardiomyopathy patients.Scientific reports · 2023Article
- Computational Modeling Studies of the Roles of Left Ventricular Geometry, Afterload, and Muscle Contractility on Myocardial Strains in Heart Failure with Preserved Ejection Fraction.Journal of cardiovascular translational research · 2021Article
- Biomechanics of Human Fetal Hearts with Critical Aortic Stenosis.Annals of biomedical engineering · 2021Article
- Mending a broken heart:Disease models & mechanisms · 2021Review
- Role of coronary flow regulation and cardiac-coronary coupling in mechanical dyssynchrony associated with right ventricular pacing.American journal of physiology. Heart and circulatory physiology · 2021Article
- Mechanical stimuli for left ventricular growth during pressure overload.Experimental mechanics · 2021Article
- Effects of myocardial function and systemic circulation on regional coronary perfusion.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Overview of mathematical modeling of myocardial blood flow regulation.American journal of physiology. Heart and circulatory physiology · 2020Review
- Effects of Mechanical Dyssynchrony on Coronary Flow: Insights From a Computational Model of Coupled Coronary Perfusion With Systemic Circulation.Frontiers in physiology · 2020Article
- Impact of Aortic Stenosis on Myofiber Stress: Translational Application of Left Ventricle-Aortic Coupling Simulation.Frontiers in physiology · 2020Article
- Multiscale Modeling Framework of Ventricular-Arterial Bi-directional Interactions in the Cardiopulmonary Circulation.Frontiers in physiology · 2020Article
- In-silico assessment of the effects of right ventricular assist device on pulmonary arterial hypertension using an image based biventricular modeling framework.Mechanics research communications · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
While it has long been recognized that bi-directional interaction between the heart and the vasculature plays a critical role in the proper functioning of the cardiovascular system, a comprehensive study of this interaction has largely been hampered by a lack of modeling framework capable of simultaneously accommodating high-resolution models of the heart and vasculature. Here, we address this issue and present a computational modeling framework that couples finite element (FE) models of the left ventricle (LV) and aorta to elucidate ventricular-arterial coupling in the systemic circulation. We show in a baseline simulation that the framework predictions of (1) LV pressure-volume loop, (2) aorta pressure-diameter relationship, (3) pressure-waveforms of the aorta, LV, and left atrium (LA) over the cardiac cycle are consistent with the physiological measurements found in healthy human. To develop insights of ventricular-arterial interactions, the framework was then used to simulate how alterations in the geometrical or, material parameter(s) of the aorta affect the LV and vice versa. We show that changing the geometry and microstructure of the aorta model in the framework led to changes in the functional behaviors of both LV and aorta that are consistent with experimental observations. On the other hand, changing contractility and passive stiffness of the LV model in the framework also produced changes in both the LV and aorta functional behaviors that are consistent with physiology principles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.