ArticleFrontiers in cellular neuroscience2018
Precision of Classification of Odorant Value by the Power of Olfactory Bulb Oscillations Is Altered by Optogenetic Silencing of Local Adrenergic Innervation.
Article in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Projection-specific Routing of Odor Information in the Olfactory Cortex.bioRxiv : the preprint server for biology · 2025Article
- Closed-Loop Optogenetic Stimulation of the Olfactory Circuit at Different Phases of Theta Oscillations of the Local Field Potential.Methods in molecular biology (Clifton, N.J.) · 2025Article
- [Application of optogenetic technology in the research on olfactory bulb neural projection from advanced brain regions to regulate olfactory signal processing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- The Response Dynamics and Function of Cholinergic and GABAergic Neurons in the Basal Forebrain During Olfactory Learning.Frontiers in cellular neuroscience · 2022Article
- Olfactory Optogenetics: Light Illuminates the Chemical Sensing Mechanisms of Biological Olfactory Systems.Biosensors · 2021Review
- Extrinsic neuromodulation in the rodent olfactory bulb.Cell and tissue research · 2021Review
- Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb.eLife · 2020Article
- Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning.Frontiers in cellular neuroscience · 2020Article
- Complex neural representation of odour information in the olfactory bulb.Acta physiologica (Oxford, England) · 2020Review
- Task-Demand-Dependent Neural Representation of Odor Information in the Olfactory Bulb and Posterior Piriform Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Aversive learning-induced plasticity throughout the adult mammalian olfactory system: insights across development.Journal of bioenergetics and biomembranes · 2019Review
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Authors and funding
3 authors.
Funding
Abstract
Neuromodulators such as noradrenaline appear to play a crucial role in learning and memory. The goal of this study was to determine the role of norepinephrine in representation of odorant identity and value by olfactory bulb oscillations in an olfactory learning task. We wanted to determine whether the different bandwidths of olfactory bulb oscillations encode information involved in associating the odor with the value, and whether norepinephrine is involved in modulating this association. To this end mice expressing halorhodopsin under the dopamine-beta-hydrolase (DBH) promoter received an optetrode implant targeted to the olfactory bulb. Mice learned to differentiate odorants in a go-no-go task. A receiver operating characteristic (ROC) analysis showed that there was development of a broadband differential rewarded vs. unrewarded odorant-induced change in the power of local field potential oscillations as the mice became proficient in discriminating between two odorants. In addition, the change in power reflected the value of the odorant rather than the identity. Furthermore, optogenetic silencing of local noradrenergic axons in the olfactory bulb altered the differential oscillatory power response to the odorants for the theta, beta, and gamma bandwidths.
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