ArticleJournal of pain research2018
Mast cell deficiency attenuates acupuncture analgesia for mechanical pain using c-kit gene mutant rats.
Article in Journal of pain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 24 citations in OpenAlex.
- Clinical characteristics of acupoint sensitization in patients with essential hypertension: a cross-sectional matched case-control study.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- CHRNA3⁺ nociceptors prime the cutaneous sensory interface to enhance electroacupuncture analgesia.Chinese medicine · 2026Article
- Mechanical cues as immunomodulators in neuroinflammation-driven spinal sensitization: analgesic mechanisms and therapeutic strategies.Frontiers in immunology · 2026Review
- Stimulation of High-Conductivity Points in Human Skin Reduces Biotin Levels to Modulate Intracellular Metabolism and Local Energy Production.Health science reports · 2025Article
- Acupoint massage: a comprehensive descriptive review of its forms, applications, and underlying mechanisms.Chinese medicine · 2025Review
- Integrative Multi-omics Analysis to Characterize Herpes Virus Infection Increases the Risk of Alzheimer's Disease.Molecular neurobiology · 2024Article
- Song's Mast Cell Theory of Acupuncture.Medical acupuncture · 2022Article
- Mast Cells and Acupuncture Analgesia.Cells · 2022Review
- Review
- Transcutaneous electrical acupoint stimulation combined with electroacupuncture promotes rapid recovery after abdominal surgery: Study protocol for a randomized controlled trial.Frontiers in public health · 2022Article
- Initiation of Acupoint Molecular Mechanisms for Manual Acupuncture Analgesia-Nuclear Factor κB Signaling Pathway.Chinese journal of integrative medicine · 2021Article
- Article
- Needling Interventions for Sciatica: Choosing Methods Based on Neuropathic Pain Mechanisms-A Scoping Review.Journal of clinical medicine · 2021Article
- Increasing Efficiency of Repetitive Electroacupuncture on Purine- and Acid-Induced Pain During a Three-Week Treatment Schedule.Frontiers in pharmacology · 2021Article
- Purinergic signaling as a basis of acupuncture-induced analgesia.Purinergic signalling · 2020Review
- Functional MRI Investigation of Ultrasound Stimulation at ST 36.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- TIMP-1 Attenuates the Development of Inflammatory Pain Through MMP-Dependent and Receptor-Mediated Cell Signaling Mechanisms.Frontiers in molecular neuroscience · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcupuncture therapy plays a pivotal role in pain relief, and increasing evidence demonstrates that mast cells (MCs) may mediate acupuncture analgesia. The present study aims to investigate the role of MCs in acupuncture analgesia using MATERIALS AND
methodsWsRC-Ws/Ws rats and their wild-type (WT) littermates (WsRC-+/+) were used. The number of MCs in skin of ST36 area was compared in two rats after immunofluorescence labeling. Mechanical withdrawal latency (MWL), mechanical withdrawal threshold (MWT), and thermal withdrawal latency (TWL) were measured on bilateral plantar for pain threshold evaluation before and after each stimulus. Acupuncture- and moxibustion-like stimuli (43°C, 46°C heat, 1 mA electroacupuncture [EA], 3 mA EA, and manual acupuncture [MA]) were applied randomly on different days.
resultsFewer MCs were observed in the skin of ST36 in mutant rats compared to WT rats (
conclusionMCs influence the basic mechanical but not thermal pain threshold. MCs participate in acupuncture analgesia in mechanical but not in thermal nociception, in that MC deficiency may attenuate the mechanical analgesia evoked by high-intensity stimuli and eliminate analgesia provoked by low-intensity stimuli.
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