ArticleThe Journal of pediatrics2018
The Impact of Maternal Antibiotics on Neonatal Disease.
Article in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed.
- Effect of early antibiotic exposure on necrotizing enterocolitis and growth in extremely preterm infants.Pediatric research · 2025Trial
- Development and Validation of a Diagnostic Prediction Model for Neonatal Sepsis in a Low-Resource Setting, Ethiopia.Journal of epidemiology and global health · 2025Article
- The double-edged sword of early antibiotic exposure in extremely preterm infants: implications for necrotizing enterocolitis and growth faltering.Pediatric research · 2025Article
- CitH3, a Druggable Biomarker for Human Diseases Associated with Acute NETosis and Chronic Immune Dysfunction.Pharmaceutics · 2025Review
- Effect of prenatal antibiotics on breast milk and neonatal IgA and microbiome: a case-control translational study protocol.Pediatric research · 2025Article
- Effect of Maternal Antibiotics on Preterm Neonatal Outcomes: A Retrospective Cohort Study.Indian journal of pediatrics · 2024Article
- Early antibiotics and risk for necrotizing enterocolitis in premature infants: A narrative review.Frontiers in pediatrics · 2023Review
- Improving Cohort-Hospital Matching Accuracy through Standardization and Validation of Participant Identifiable Information.Children (Basel, Switzerland) · 2022Article
- Fetal-neonatal exposure to antibiotics and NEC development: A systematic review and meta-analysis.Frontiers in pediatrics · 2022Review
- Antenatal Antibiotic Exposure Affects Enteral Feeding, Body Growth, and Neonatal Infection in Preterm Infants: A Retrospective Study.Frontiers in pediatrics · 2021Article
- Maternal Antibiotic Treatment Disrupts the Intestinal Microbiota and Intestinal Development in Neonatal Mice.Frontiers in microbiology · 2021Article
- Preventing dysbiosis of the neonatal mouse intestinal microbiome protects against late-onset sepsis.Nature medicine · 2019Article
- Uncertainties in Screening and Prevention of Group B Streptococcus Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- A critical analysis of risk factors for necrotizing enterocolitis.Seminars in fetal & neonatal medicine · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesWe examined the impact of prenatal exposure to maternal antibiotics on risk of necrotizing enterocolitis (NEC), late onset sepsis (LOS), and death in infants born preterm. STUDY
designSecondary data analysis was conducted via an extant cohort of 580 infants born <32 weeks of gestation and enrolled in 3 level III neonatal intensive care units. Prenatal antibiotic exposure was defined as antibiotics received by the mother within 72 hours before delivery. Postnatal empiric antibiotic exposure was defined as antibiotic initiated within the first day of life without documented infection, categorized as low (<5 days) or high (>5 days) duration.
resultsTwo-thirds of mothers received antibiotics within 72 hours before delivery, of whom 59.8% received >1 antibiotic. Ampicillin (37.6%) and azithromycin (26.4%) were the most common antibiotics given. NEC occurred in 7.5%, LOS in 11.1%, death in 9.6%, and the combined outcome of NEC, LOS, or death in 21.3% of study infants. In multiple logistic regression models adjusted for gestational age, postnatal empiric antibiotic exposure, and other factors, prenatal antibiotic exposure was associated with reduced risk of NEC (OR 0.28; 95% CI 0.14-0.56; P < .001), death (OR 0.29; 95% CI 0.14-0.60; P = .001), but not LOS (OR 1.59; 95% CI 0.84-2.99; P = .15), although protection was significant for the combined outcome (OR 0.52, P < .001). High postnatal empiric antibiotic exposure was associated with greater risk of death but not other outcomes in multiple regression models (OR 3.18, P = .002).
conclusionsPrenatal antibiotic exposure was associated with lower rates of NEC or death of infants born preterm, and its impact on infant outcomes warrants further study.
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