Evidence map›Paper›PMID 29551269›Full record

ArticleCell2018

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.

Rajiv K Khajuria, Mathias Munschauer, Jacob C Ulirsch, Claudia Fiorini, Leif S Ludwig, Sean K McFarland, Nour J Abdulhay, Harrison Specht, Hasmik Keshishian, D R Mani and 17 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 277 papers.

0numbers the graph read from it
0cells of the map it votes in
277citing papers in PubMed
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

277 citing papers in PubMed, 419 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Declining ribosome function limits oocyte longevity.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Genetic influences on haematopoiesis.Nature reviews. Genetics · 2026
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Science advances · 2026
    Article
  18. DCAF13 Safeguards Hematopoietic Stem Cells via RRS1-Regulated Ribosome Biogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  19. Article
  20. Article

217 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 11 institutions in 3 countries.

Rajiv K KhajuriaDivision of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin 13353, Germany.
Mathias MunschauerBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jacob C UlirschDivision of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Claudia FioriniDivision of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Leif S LudwigDivision of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Sean K McFarlandDivision of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Nour J AbdulhayDivision of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Harrison SpechtBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Hasmik KeshishianBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
D R ManiBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Marko JovanovicBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Steven R EllisDepartment of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40202, USA.
Charles P FulcoBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jesse M EngreitzBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Sabina SchützInstitute of Medical Microbiology, Department of Medicine, University of Zurich, 8006 Zurich, Switzerland.
John LianInstitute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA; Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA.
Karen W GrippDivision of Medical Genetics, A. I. duPont Hospital for Children, Wilmington, DE 19803, USA.
Olga K WeinbergDepartment of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.
Geraldine S PinkusDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Lee GehrkeInstitute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA; Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA.
Aviv RegevBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Eric S LanderBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Hanna T GazdaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Winston Y LeeDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Vikram G PanseInstitute of Medical Microbiology, Department of Medicine, University of Zurich, 8006 Zurich, Switzerland.
Steven A CarrBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Vijay G SankaranDivision of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: sankaran@broadinstitute.org.
Broad Institute · USBoston Children's Hospital · USDana-Farber Cancer Institute · USHarvard University · USUniversity of Zurich · CHBrigham and Women's Hospital · USCharité - Universitätsmedizin Berlin · DECommunity Health Systems - Dupont Hospital · USDana-Farber/Boston Children's Cancer and Blood Disorders Center · USMassachusetts Institute of Technology · USUniversity of Louisville · US

Funding

PATHOPHYSIOLOGY OF HUMAN BLOOD CELLST32HL007574 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Daniel Evan Bauer · 1985 to 2026
$18.4M
Systematic Genetic Dissection of Human ErythropoiesisR01DK103794 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Vijay Ganesh Sankaran · 2014 to 2026
$5.9M
Identifying Genome-wide Association Study-Nominated Regulators of ErythropoiesisR33HL120791 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI SANKARAN, VIJAY GANESH · 2016 to 2018
$1.7M
Howard Hughes Medical InstituteNHLBI NIH HHS R33 HL120791NHLBI NIH HHS T32 HL007574NIDDK NIH HHS R01 DK103794
6 · The paper itself

Abstract

Blood cell formation is classically thought to occur through a hierarchical differentiation process, although recent studies have shown that lineage commitment may occur earlier in hematopoietic stem and progenitor cells (HSPCs). The relevance to human blood diseases and the underlying regulation of these refined models remain poorly understood. By studying a genetic blood disorder, Diamond-Blackfan anemia (DBA), where the majority of mutations affect ribosomal proteins and the erythroid lineage is selectively perturbed, we are able to gain mechanistic insight into how lineage commitment is programmed normally and disrupted in disease. We show that in DBA, the pool of available ribosomes is limited, while ribosome composition remains constant. Surprisingly, this global reduction in ribosome levels more profoundly alters translation of a select subset of transcripts. We show how the reduced translation of select transcripts in HSPCs can impair erythroid lineage commitment, illuminating a regulatory role for ribosome levels in cellular differentiation.

Indexed as

5' Untranslated RegionsAnemia, Diamond-BlackfanApoptosis Regulatory ProteinsBone Marrow CellsCells, CulturedFemaleGATA1 Transcription FactorHematopoietic Stem CellsHumansMaleMutation, MissenseRibosomal ProteinsRibosomesRNA InterferenceRNA, Small InterferingTranscription Factors5' Untranslated RegionsApoptosis Regulatory ProteinsGATA1 protein, humanGATA1 Transcription Factorribosomal protein L5, humanRibosomal Proteinsribosomal protein S19RNA, Small InterferingTranscription FactorsTSR2 protein, humanDiamond-Blackfan anemiaerythropoiesisGATA1geneticshematopoiesislineage commitmentribosometranslation

Identifiers

PMID29551269
PMCPMC5866246
OpenAlexW2793800931

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.