ArticleJournal of the American Chemical Society2018
Photoswitching of DNA Hybridization Using a Molecular Motor.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Dynamic Control of Nucleic Acids Self-Assembly and Expression Using Photoswitches.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Utilizing Light to Control Glycopolymer-DC-SIGN Interactions via Molecular Motors.Journal of the American Chemical Society · 2026Article
- AIEgen-mediated integration of plain DNA and hydrophobic compounds enabling three-in-one nanosystems for carrier-free delivery.Journal of nanobiotechnology · 2026Article
- Omega Nucleic Acids (ΩNA), Ultimate Nucleic Acids for Future Technology.Molecules (Basel, Switzerland) · 2026Review
- Plain DNA and cationic aromatics: a platform to simplify carrier-free delivery systems.Journal of nanobiotechnology · 2025Article
- Cold-Captured Dynamic Hydration Networks in Oxime-Based Photoswitches: A Theoretical Challenge Uncovered by Rotational Spectroscopy.Angewandte Chemie (International ed. in English) · 2025Article
- Microhydration Dynamics in Molecular Photoswitches: Equilibrium State Reconfiguration in Imine-Based Architectures.Angewandte Chemie (International ed. in English) · 2025Article
- Designing Reversible Photoswitching Azobenzene-Modified Nucleotide for Controlling Biological Function.Journal of the American Chemical Society · 2025Article
- Article
- Recent Progress in Regulating the Activity of Enzymes with Photoswitchable Inhibitors.Molecules (Basel, Switzerland) · 2024Review
- Bimodal DNA self-origami material with nucleic acid function enhancement.Journal of nanobiotechnology · 2024Article
- A visible-light-driven molecular motor based on barbituric acid.Chemical science · 2023Article
- Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations.Nature communications · 2023Article
- Accounts of applied molecular rotors and rotary motors: recent advances.Nanoscale advances · 2023Review
- Martini 3 Coarse-Grained Model for Second-Generation Unidirectional Molecular Motors and Switches.Journal of chemical theory and computation · 2023Article
- Controllable DNA hybridization by host-guest complexation-mediated ligand invasion.Nature communications · 2022Article
- Chemically Driven Rotatory Molecular Machines.Angewandte Chemie (International ed. in English) · 2022Review
- Light responsive nucleic acid for biomedical application.Exploration (Beijing, China) · 2022Review
- Article
- Controlling rotary motion of molecular motors based on oxindole.Organic chemistry frontiers : an international journal of organic chemistry · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reversible control over the functionality of biological systems via external triggers may be used in future medicine to reduce the need for invasive procedures. Additionally, externally regulated biomacromolecules are now considered as particularly attractive tools in nanoscience and the design of smart materials, due to their highly programmable nature and complex functionality. Incorporation of photoswitches into biomolecules, such as peptides, antibiotics, and nucleic acids, has generated exciting results in the past few years. Molecular motors offer the potential for new and more precise methods of photoregulation, due to their multistate switching cycle, unidirectionality of rotation, and helicity inversion during the rotational steps. Aided by computational studies, we designed and synthesized a photoswitchable DNA hairpin, in which a molecular motor serves as the bridgehead unit. After it was determined that motor function was not affected by the rigid arms of the linker, solid-phase synthesis was employed to incorporate the motor into an 8-base-pair self-complementary DNA strand. With the photoswitchable bridgehead in place, hairpin formation was unimpaired, while the motor part of this advanced biohybrid system retains excellent photochemical properties. Rotation of the motor generates large changes in structure, and as a consequence the duplex stability of the oligonucleotide could be regulated by UV light irradiation. Additionally, Molecular Dynamics computations were employed to rationalize the observed behavior of the motor-DNA hybrid. The results presented herein establish molecular motors as powerful multistate switches for application in biological environments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.