Evidence map›Paper›PMID 29550935›Full record

Observational studyJournal of endocrinological investigation2018

Clinicopathologic risk factors for right paraesophageal lymph node metastasis in patients with papillary thyroid carcinoma.

Q A Yu, D K Ma, K P Liu, P Wang, C M Xie, Y H Wu, W J Dai, H C Jiang

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of endocrinological investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Q A YuDepartment of Thyroid Surgery, The First Affiliated Hospital Harbin Medical University, Harbin, 150001, Heilongjiang, China.
D K MaDepartment of Thyroid Surgery, The First Affiliated Hospital Harbin Medical University, Harbin, 150001, Heilongjiang, China.
K P LiuDepartment of Thyroid Surgery, The First Affiliated Hospital Harbin Medical University, Harbin, 150001, Heilongjiang, China.
P WangOperating Room, The First Affiliated Hospital Harbin Medical University, Harbin, 150001, China.
C M XieDepartment of Thyroid Surgery, The First Affiliated Hospital Harbin Medical University, Harbin, 150001, Heilongjiang, China.
Y H WuDepartment of Thyroid Surgery, The First Affiliated Hospital Harbin Medical University, Harbin, 150001, Heilongjiang, China.
W J DaiDepartment of Thyroid Surgery, The First Affiliated Hospital Harbin Medical University, Harbin, 150001, Heilongjiang, China. davidhmu@163.com.
H C JiangDepartment of Liver Surgery, The First Affiliated Hospital Harbin Medical University, Harbin, 150001, Heilongjiang, China. jianghc@vip.163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate risk factors associated with right paraesophageal lymph node (RPELN) metastasis in patients with papillary thyroid carcinoma (PTC) and to determine the indications for right lymph node dissection.

methodsClinicopathologic data from 829 patients (104 men and 725 women) with PTC, operated on by the same thyroid surgery team at the First Affiliated Hospital of Harbin Medical University from January 2013 to May 2017, were analyzed. Overall, 309 patients underwent total thyroidectomy with bilateral lymph node dissection, 488 underwent right thyroid lobe and isthmic resection with right central compartment lymph node dissection, and 32 underwent near-total thyroidectomy (ipsilateral thyroid lobectomy with contralateral near-total lobectomy) with bilateral lymph node dissection.

resultsThe overall rate of central compartment lymph node metastasis was 43.5% (361/829), with right central compartment lymph node and RPELN metastasis rates of 35.5% (294/829) and 19.1% (158/829), respectively. Tumor size, number, invasion, and location, lymph node metastasis, right central compartment lymph node metastasis, and right lateral compartment lymph node metastasis were associated with RPELN in the univariate analysis, whereas age and sex were not. Multivariate analysis identified tumors with a diameter ≥ 1 cm, multiple tumors, tumors located in the right lobe, right central compartment lymph node metastasis, and right lateral compartment lymph node metastasis as independent risk factors for RPELN metastasis.

conclusionsLymph node dissection, including RPELN dissection, should be performed for patients with PTC with a tumor diameter ≥ 1 cm, multiple tumors, right-lobe tumors, right central compartment lymph node metastasis, or suspected lateral compartment lymph node metastasis.

Indexed as

AdultCarcinoma, PapillaryFemaleHumansLymphatic MetastasisLymph NodesMaleMiddle AgedRetrospective StudiesRisk FactorsThyroid NeoplasmsLymph node dissectionMetastasisPapillary thyroid carcinoma (PTC)Right paraesophageal lymph node

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.