Evidence map›Paper›PMID 29550918›Full record

ArticleMolecular neurobiology2018

Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7.

Supawadee Sukseree, Lajos László, Florian Gruber, Sophie Bergmann, Marie Sophie Narzt, Ionela Mariana Nagelreiter, Romana Höftberger, Kinga Molnár, Günther Rauter, Thomas Birngruber and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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  7. Autophagic Control of Skin Aging.Frontiers in cell and developmental biology · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Supawadee SuksereeResearch Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Lazarettgasse 14, 1090, Vienna, Austria.
Lajos LászlóDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.
Florian GruberResearch Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Lazarettgasse 14, 1090, Vienna, Austria.
Sophie BergmannResearch Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Lazarettgasse 14, 1090, Vienna, Austria.
Marie Sophie NarztResearch Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Lazarettgasse 14, 1090, Vienna, Austria.
Ionela Mariana NagelreiterResearch Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Lazarettgasse 14, 1090, Vienna, Austria.
Romana HöftbergerInstitute of Neurology, Medical University of Vienna, Vienna, Austria.
Kinga MolnárDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.
Günther RauterDivision of Biomedical Research, Medical University of Graz, Graz, Austria.
Thomas BirngruberJoanneum Research, Health - Institute for Biomedicine and Health Sciences, Graz, Austria.
Lionel LarueInstitut Curie, INSERM U1021, CNRS UMR3347, Normal and Pathological Development of Melanocytes, PSL Research University, Orsay, France.
Gabor G KovacsInstitute of Neurology, Medical University of Vienna, Vienna, Austria.
Erwin TschachlerResearch Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Lazarettgasse 14, 1090, Vienna, Austria.
Leopold EckhartResearch Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Lazarettgasse 14, 1090, Vienna, Austria. leopold.eckhart@meduniwien.ac.at.ORCID http://orcid.org/0000-0002-5645-2036
Medical University of Vienna · ATChristian Doppler Laboratory for Thermoelectricity · ATEötvös Loránd University · HUCentre National de la Recherche Scientifique · FRJoanneum Research · ATMedical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Defects in autophagy and the resulting deposition of protein aggregates have been implicated in aging and neurodegenerative diseases. While gene targeting in the mouse has facilitated the characterization of these processes in different types of neurons, potential roles of autophagy and accumulation of protein substrates in neuroepithelial cells have remained elusive. Here we report that Atg7

Indexed as

Gene DeletionProtein AggregatesAnimalsAutophagyAutophagy-Related Protein 7BrainCiliary BodyEpendymaFemaleIntegrasesMiceNeuroepithelial CellsNeuronsPhospholipidsSequestosome-1 ProteinUbiquitinAtg7 protein, mouseAutophagy-Related Protein 7Cre recombinaseIntegrasesPhospholipidsProtein AggregatesSequestosome-1 ProteinSqstm1 protein, mouseUbiquitinAutophagyChoroid plexusCortexEpendymap62Protein aggregationSequestosome-1

Identifiers

PMID29550918
PMCPMC6153718
OpenAlexW2790263624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.