Evidence map›Paper›PMID 29550911›Full record

Trial reportProbiotics and antimicrobial proteins2019

Effect of Probiotics for the Prevention of Acute Radiation-Induced Diarrhoea Among Cervical Cancer Patients: a Randomized Double-Blind Placebo-Controlled Study.

Ye Htut Linn, K Khine Thu, Nang Hla Hla Win

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Probiotics and antimicrobial proteins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03574051 (Distinct Shifts in the Microbiota Are Associated With Iodine-131 Therapy and Hypothyroidism), which is not on this map. Cited by 87 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03574051 early_phase1unknown statusnot on this map

Distinct Shifts in the Microbiota Are Associated With Iodine-131 Therapy and Hypothyroidism

TypeinterventionalSponsorFirst Affiliated Hospital of Harbin Medical UniversityRan2018 to 2022Enrolled30ConditionsMicrobiotaArmsProbiotic
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Guideline
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  11. Impact of Saccharomyces boulardii on acute gastrointestinal toxicities in patients undergoing pelvic radiotherapy for gynecologic cancers: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  12. A phase II clinical trial ofFrontiers in nutrition · 2025
    Trial
  13. Trial
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  16. Review
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  18. Probiotics Cancer Interaction, Prevention, and Therapy.Immunity, inflammation and disease · 2026
    Review
  19. Review
  20. Comparative Immunomodulatory Profiles ofJournal of microbiology and biotechnology · 2026
    Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ye Htut LinnDepartment of Pharmacology, University of Medicine 1, Yangon. No. 245, Myoma Kyaung Street, Lanmadaw Township, Yangon, Myanmar. dryehtutlinn@gmail.com.ORCID 0000-0003-0852-5218
K Khine ThuDepartment of Pharmacology, University of Medicine 1, Yangon. No. 245, Myoma Kyaung Street, Lanmadaw Township, Yangon, Myanmar.
Nang Hla Hla WinDepartment of Pharmacology, University of Medicine 1, Yangon. No. 245, Myoma Kyaung Street, Lanmadaw Township, Yangon, Myanmar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy is the mainstay treatment of cervical cancer and the most common acute side effect is radiation-induced diarrhoea (RID), which can affect up to 80% of the patients. The most frequently used probiotics for the RID in previous studies with somewhat positive results are Lactobacillus and Bifidobacterium strains. This study was aimed to investigate the effect of a probiotic containing live Lactobacillus acidophilus LA-5 plus Bifidobacterium animalis subsp. lactis BB-12 for the prevention of acute (RID) among cervical cancer patients. Patients receiving external beam pelvic radiotherapy with or without concurrent chemotherapy were randomized into probiotic or placebo groups and were double-blinded. The probiotic group received the capsules containing 1.75 billion lyophilized live bacteria to be taken one capsule three times daily beginning from the first day until the end of radiotherapy, and the placebo group received identically appearing capsules containing starch with the same schedule. Every patient received the standard dietary recommendations. The patients were assessed daily during radiotherapy and follow-up weekly for 3 weeks after radiotherapy. Total 54 patients were analyzed. The incidence of diarrhoea was reduced in the probiotic group than the placebo group (53.8 and 82.1%, p < 0.05). The mild-to-moderate and severe diarrhoea were significantly reduced in the probiotic group (p < 0.05). The use of loperamide as an anti-diarrhoeal medication was significantly reduced in the probiotic group than the placebo group (p < 0.01). The difference in grade 2 abdominal pain and episodes of abdominal pain in days were also significant (p < 0.001). Therefore, supplementation of probiotic is an easy and effective way to reduce the incidence and severity of RID in cervical cancer patients.

Indexed as

Acute DiseaseAdultDiarrheaDouble-Blind MethodFemaleHumansLoperamideMiddle AgedProbioticsRadiation InjuriesRadiotherapyUterine Cervical NeoplasmsLoperamideBifidobacteriumCervical cancerLactobacillusProbioticsRadiation-induced diarrhoea

Identifiers

PMID29550911

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.