SynthesisGenes and immunity2019
Association between interleukin family gene polymorphisms and recurrent aphthous stomatitis risk.
Synthesis in Genes and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Dynamic salivary cytokine profile of recurrent aphthous stomatitis patients in thalidomide maintenance treatment.Clinical oral investigations · 2024Trial
- Comparison of ruminal microbiota,Frontiers in microbiology · 2024Article
- IL-10 and TGF-β1 gene polymorphisms in Greek patients with recurrent aphthous stomatitis.Medicina oral, patologia oral y cirugia bucal · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was aimed at identifying the association between interleukin family gene polymorphisms and recurrent aphthous stomatitis (RAS) risk using a meta-analysis. We searched the PubMed, web of science, Embase and ScienceDirect-Elsevier databases for research on the interleukin polymorphism and RAS risk. In total 12 studies were included to investigate the relationships between RAS risk and six polymorphisms by calculating pooled odds ratios (ORs) and 95% confidence intervals (CIs). A significant association was found between IL-1β+3954C/T polymorphism and RAS risk. A high risk of RAS was found in RAS patients with the G allele or GG genotype of IL-6-174 polymorphism. Low risk of RAS was found in the C allele of IL-10-592C/A polymorphism under an allele model, but a high risk of RAS was found in IL-10-1082G/A polymorphism. In the subgroup analysis, no correlation was found between the IL-10-1082 polymorphism and RAS risk in the caucasian population with the allele model. In conclusion, an IL-1β+3954C/T polymorphism was determined to be related to susceptibility to RAS, and individuals with the G allele and GG genotype of IL-6-174 or the A allele of IL-10-592 or the G allele of IL-10-1082 appeared to be more vulnerable to developing RAS.
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Registered trials
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