ArticleEnvironment international2018
Associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic diseases among children aged 6 and 7 years.
Article in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Maternal Phthalate Exposure and Allergic Diseases in Children: A Meta-Analysis and Network Toxicology.International journal of molecular sciences · 2025Pooled it
- The banned sunscreen ingredients and their impact on human health: a systematic review.International journal of dermatology · 2020Pooled it
- Gut Microbiota Resilience and Environmental Stressors: A Hidden Key to Lifespan Optimization?Probiotics and antimicrobial proteins · 2026Review
- Pregnancy exposure to individual phthalate concentrations and their mixtures in relation to pediatric serum antibody response.European journal of epidemiology · 2026Article
- Prenatal Exposure to Phthalates, Bisphenols and Their Mixtures and Early Childhood Allergic Conditions and Asthma: Results from the APrON Cohort.International journal of environmental research and public health · 2025Article
- Article
- Association of prenatal exposure to phthalates with risks of asthma, wheeze, and allergic diseases during childhood: a systematic review and meta-analysis.Journal of environmental health science & engineering · 2025Article
- Field cancerization, accelerated aging, and immunosuppression: the rapid rise of hormone-sensitive and early-onset breast cancer.NPJ breast cancer · 2025Review
- Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort.Environment international · 2025Article
- Associations Between Prenatal Phthalate Exposure and Atopic Symptoms in Childhood: Effect Modification by Child Sex.Toxics · 2025Article
- Prenatal exposure to environmental bisphenols over time and their association with childhood asthma, allergic rhinitis and atopic dermatitis in the ECHO consortium.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Association between urinary exposures and the risk of chronic obstructive pulmonary disease in smokers: results from NHANES 2007-2016.Frontiers in public health · 2025Article
- Prenatal exposure to phthalates and childhood wheeze and asthma in the PROGRESS cohort.The Science of the total environment · 2024Article
- Discovery and Validation of a Volatile Signature of Eosinophilic Airway Inflammation in Asthma.American journal of respiratory and critical care medicine · 2024Article
- Urinary biomarkers of environmental exposures and asthma morbidity in a school inner city asthma study.International journal of hygiene and environmental health · 2024Article
- Associations of prenatal exposure to phthalates and their mixture with lung function in Mexican children.Journal of hazardous materials · 2024Article
- Association between DCP levels and kidney stone prevalence in US female adults based on NHANES data.Scientific reports · 2024Article
- Prenatal exposure to replacement flame retardants and organophosphate esters and childhood adverse respiratory outcomes.Environmental research · 2024Article
- Health Risk Assessment of Occupational Exposures of Polycyclic Aromatic Hydrocarbons, Phthalates, and Semi-Volatile Chlorinated Organic Compounds in Urine of Commercial Fish Smokers, Ghana.Environmental health insights · 2024Article
- Synthetic Chemicals: What We Have Learned and Still Need to Learn About Their Associations with Childhood Allergy and Asthma.Current environmental health reports · 2023Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPrenatal environmental phenol and phthalate exposures may alter immune or inflammatory responses leading to respiratory and allergic disease.
objectivesWe estimated associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic outcomes among children in the Mount Sinai Children's Environmental Health Study.
methodsWe quantified urinary biomarkers of benzophenone-3, bisphenol A, paradichlorobenzene (as 2,5-dichlorophenol), triclosan, and 10 phthalate metabolites in third trimester maternal samples and assessed asthma, wheeze, and atopic skin conditions via parent questionnaires at ages 6 and 7 years (n = 164 children with 240 observations). We used logistic regression to estimate covariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) per standard deviation difference in natural log biomarker concentrations and examined effect measure modification by child's sex.
resultsAssociations of prenatal 2,5-dichlorophenol (all outcomes) and bisphenol A (asthma outcomes) were modified by child's sex, with increased odds of outcomes among boys but not girls. Among boys, ORs for asthma diagnosis per standard deviation difference in biomarker concentration were 3.00 (95% CI: 1.36, 6.59) for 2,5-dichlorophenol and 3.04 (95% CI: 1.38, 6.68) for bisphenol A. Wheeze in the past 12 months was inversely associated with low molecular weight phthalate metabolites among girls only (OR: 0.27, 95% CI: 0.13, 0.59) and with benzophenone-3 among all children (OR: 0.65, 95% CI: 0.44, 0.96).
conclusionsPrenatal bisphenol A and paradichlorobenzene exposures were associated with pediatric respiratory outcomes among boys. Future studies may shed light on biological mechanisms and potential sexually-dimorphic effects of select phenols and phthalates on respiratory disease development.
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