ArticleNeuropsychologia2018
The impact of sample size on the reproducibility of voxel-based lesion-deficit mappings.
Article in Neuropsychologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural and functional brain abnormal alteration in patients with type 2 diabetes mellitus: A coordinate-based meta-analysis.Translational psychiatry · 2025Pooled it
- Predicting Outcomes of Language Rehabilitation: Prognostic Factors for Immediate and Long-Term Outcomes After Aphasia Therapy.Journal of speech, language, and hearing research : JSLHR · 2023Trial
- Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients.Stroke and vascular neurology · 2022Trial
- Methodological Choices Strongly Modulate the Sensitivity and Specificity of Lesion-Symptom Mapping Analyses.Human brain mapping · 2026Article
- Extension of voxel-based lesion mapping to multidimensional neurophysiological data.Scientific reports · 2025Article
- Associations Between Trail-Making Test Black and White Performance and Gray Matter Volume in Community-Dwelling Cognitively Healthy Adults Aged 40 to 80 Years.Journal of clinical medicine · 2025Article
- Predictors and Implications of Myocardial Injury in Intracerebral Hemorrhage.Clinical neuroradiology · 2025Article
- Unveiling covert disownership after stroke: a neuropsychological and neural approach.Brain communications · 2025Article
- White matter tracts involved in complex regional pain syndrome after subcortical stroke.Frontiers in neurology · 2025Article
- Anatomical predictors of gastrostomy tube placement after large vessel occlusion ischemic stroke.Frontiers in neurology · 2025Article
- Transient Attention Gates Access Consciousness: Coupling N2pc and P3 Latencies Using Dynamic Time Warping.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Lesion-symptom Mapping of Acceptability Judgments in Chronic Poststroke Aphasia Reveals the Neurobiological Underpinnings of Receptive Syntax.Journal of cognitive neuroscience · 2024Article
- Altered hierarchical auditory predictive processing after lesions to the orbitofrontal cortex.eLife · 2024Article
- A large public dataset of annotated clinical MRIs and metadata of patients with acute stroke.Scientific data · 2023Article
- Listening to Yourself and Watching Your Tongue: Distinct Abilities and Brain Regions for Monitoring Semantic and Phonological Speech Errors.Journal of cognitive neuroscience · 2023Article
- Predictors of Therapy Response in Chronic Aphasia: Building a Foundation for Personalized Aphasia Therapy.Journal of stroke · 2022Review
- Structural disconnection of the posterior medial frontal cortex reduces speech error monitoring.NeuroImage. Clinical · 2022Article
- Brain age predicts long-term recovery in post-stroke aphasia.Brain communications · 2022Article
- Research on bilingualism as discovery science.Brain and language · 2021Article
- The meaning of significant mean group differences for biomarker discovery.PLoS computational biology · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
This study investigated how sample size affects the reproducibility of findings from univariate voxel-based lesion-deficit analyses (e.g., voxel-based lesion-symptom mapping and voxel-based morphometry). Our effect of interest was the strength of the mapping between brain damage and speech articulation difficulties, as measured in terms of the proportion of variance explained. First, we identified a region of interest by searching on a voxel-by-voxel basis for brain areas where greater lesion load was associated with poorer speech articulation using a large sample of 360 right-handed English-speaking stroke survivors. We then randomly drew thousands of bootstrap samples from this data set that included either 30, 60, 90, 120, 180, or 360 patients. For each resample, we recorded effect size estimates and p values after conducting exactly the same lesion-deficit analysis within the previously identified region of interest and holding all procedures constant. The results show (1) how often small effect sizes in a heterogeneous population fail to be detected; (2) how effect size and its statistical significance varies with sample size; (3) how low-powered studies (due to small sample sizes) can greatly over-estimate as well as under-estimate effect sizes; and (4) how large sample sizes (N ≥ 90) can yield highly significant p values even when effect sizes are so small that they become trivial in practical terms. The implications of these findings for interpreting the results from univariate voxel-based lesion-deficit analyses are discussed.
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