Evidence map›Paper›PMID 29550471›Full record

ReviewBiochemical and biophysical research communications2018

Mammalian nonmuscle myosin II comes in three flavors.

Maria S Shutova, Tatyana M Svitkina

Abstract readReview
In one paragraph

Review in Biochemical and biophysical research communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Nonmuscle myosin 2 turnover in cells is synergistically controlled by the tail and the motor domain.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Engineering filamentous myosins for optical control of contractility.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Structure, regulation, and mechanisms of nonmuscle myosin-2.Cellular and molecular life sciences : CMLS · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Oscillators in the microvasculature: glycocalyx and beyond.American journal of physiology. Cell physiology · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria S ShutovaDepartment of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Tatyana M SvitkinaDepartment of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address: svitkina@sas.upenn.edu.
University of Pennsylvania · US

Funding

Multifaceted roles of nonmuscle myosin II in cell adhesion and migrationR01GM095977 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SVITKINA, TATYANA · 2013 to 2020
$2.7M
NIGMS NIH HHS R01 GM095977
6 · The paper itself

Abstract

Nonmuscle myosin II is an actin-based motor that executes numerous mechanical tasks in cells including spatiotemporal organization of the actin cytoskeleton, adhesion, migration, cytokinesis, tissue remodeling, and membrane trafficking. Nonmuscle myosin II is ubiquitously expressed in mammalian cells as a tissue-specific combination of three paralogs. Recent studies reveal novel specific aspects of their kinetics, intracellular regulation and functions. On the other hand, the three paralogs also can copolymerize and cooperate in cells. Here we review the recent advances from the prospective of how distinct features of the three myosin II paralogs adapt them to perform specialized and joint tasks in the cell.

Indexed as

Actin CytoskeletonActinsAnimalsBiomechanical PhenomenaCell AdhesionCell MovementCytokinesisEukaryotic CellsExtracellular MatrixGene ExpressionHumansMammalsMyosin Heavy ChainsMyosin Type IINonmuscle Myosin Type IIANonmuscle Myosin Type IIBActinsMYH7b protein, humanMyosin Heavy ChainsMyosin Type IINonmuscle Myosin Type IIANonmuscle Myosin Type IIBActinCytoskeletonMyosin IIStress fibers

Identifiers

PMID29550471
PMCPMC6139281
OpenAlexW2794052135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.