Evidence map›Paper›PMID 29550367›Full record

ReviewNeurobiology of learning and memory2019

Contemporary strategies for dissecting the neuronal basis of neurodevelopmental disorders.

Dong-Oh Seo, Laura E Motard, Michael R Bruchas

Open access · greenAbstract readReview
In one paragraph

Review in Neurobiology of learning and memory, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. A missense mutation inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  2. Review
  3. The ontogeny of memory persistence and specificity.Developmental cognitive neuroscience · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dong-Oh SeoDepartmentof Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO 63110, United States.
Laura E MotardDepartmentof Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, United States.
Michael R BruchasDepartmentof Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, United States; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO 63110, United States; Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, United States. Electronic address: bruchasm@wustl.edu.
Washington University in St. Louis · US

Funding

Decoding Locus Coeruleus Neural Circuits and Signaling In Negative AffectR01MH112355 · NIMH · WASHINGTON UNIVERSITY · PI Michael R. Bruchas · 2016 to 2026
$5.3M
AN INDUCIBLE MOLECULAR MEMORY SYSTEM TO RECORD TRANSIENT STATES OF CNS CELLSU01MH109133 · NIMH · WASHINGTON UNIVERSITY · PI MITRA, ROBI D · 2015 to 2017
$3.6M
NIMH NIH HHS R01 MH112355NIMH NIH HHS U01 MH109133
6 · The paper itself

Abstract

Great efforts in clinical and basic research have shown progress in understanding the neurobiological mechanisms of neurodevelopmental disorders, such as autism, schizophrenia, and attention-deficit hyperactive disorders. Literature on this field have suggested that these disorders are affected by the complex interaction of genetic, biological, psychosocial and environmental risk factors. However, this complexity of interplaying risk factors during neurodevelopment has prevented a complete understanding of the causes of those neuropsychiatric symptoms. Recently, with advances in modern high-resolution neuroscience methods, the neural circuitry analysis approach has provided new solutions for understanding the causal relationship between dysfunction of a neural circuit and behavioral alteration in neurodevelopmental disorders. In this review we will discuss recent progress in developing novel optogenetic and chemogenetic strategies to investigate neurodevelopmental disorders.

Indexed as

AnimalsAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderHumansNeurodevelopmental DisordersNeuronsObsessive-Compulsive DisorderOptogeneticsSchizophreniaAutismChemogeneticsIDDNeurodevelopmentOptogeneticsSchizophrenia

Identifiers

PMID29550367
PMCPMC6138573
OpenAlexW2790622114

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.