Evidence map›Paper›PMID 29550351›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2018

Peripubertal serum dioxin concentrations and subsequent sperm methylome profiles of young Russian adults.

J Richard Pilsner, Alex Shershebnev, Yulia A Medvedeva, Alexander Suvorov, Haotian Wu, Andrey Goltsov, Evgeny Loukianov, Tatiana Andreeva, Fedor Gusev, Andrey Manakhov and 12 more

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In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

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  6. Risk factors on testicular function in adolescents.Journal of endocrinological investigation · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 2 countries.

J Richard PilsnerDepartment of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, 686 North Pleasant Street, Amherst, MA, 01003, USA. Electronic address: rpilsner@umass.edu.
Alex ShershebnevDepartment of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, 686 North Pleasant Street, Amherst, MA, 01003, USA. Electronic address: ashershebnev@gmail.com.
Yulia A MedvedevaInstitute of Bioengineering, Research Center of Biotechnology Russian Academy of Sciences, 60 let Oktjabrja pr-t, 7, Bld. 1, 117312, Moscow, Russia; Department of Computational Biology, Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkina St., 119991, Moscow, Russia. Electronic address: ju.medvedeva@gmail.com.
Alexander SuvorovDepartment of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, 686 North Pleasant Street, Amherst, MA, 01003, USA. Electronic address: asuvorov@schoolph.umass.edu.
Haotian WuDepartment of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, 686 North Pleasant Street, Amherst, MA, 01003, USA. Electronic address: haotianw@umass.edu.
Andrey GoltsovDepartment of Molecular Genetics, Research Center for Obstetrics, Gynecology and Perinatology, 4 Oparin St., 117997, Moscow, Russia; Department of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkina St., 119991, Moscow, Russia. Electronic address: andrey.goltsov@gmail.com.
Evgeny LoukianovDepartment of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkina St., 119991, Moscow, Russia. Electronic address: loukiaev@yandex.ru.
Tatiana AndreevaDepartment of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkina St., 119991, Moscow, Russia. Electronic address: an_tati@mail.ru.
Fedor GusevDepartment of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkina St., 119991, Moscow, Russia. Electronic address: gusevfe@gmail.com.
Andrey ManakhovDepartment of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkina St., 119991, Moscow, Russia. Electronic address: andrey-manakhov@yandex.ru.
Luidmila SmigulinaChapaevsk Medical Association, 3a Meditsinskaya st., 446100, Chapaevsk, Samara region, Russia. Electronic address: chapmedass@samtel.ru.
Maria LogachevaA.N. Belozersky Research Institute of Physico-Chemical Biology, Moscow State University, Leninskye Gory, House 1, Building 40, 119992, Moscow, Russia; Center for Data-Intensive Biomedicine and Biotechnology, Skolkovo Institute of Science and Technology, 143028, Moscow, Russia. Electronic address: maria.log@gmail.com.
Victoria ShtratnikovaA.N. Belozersky Research Institute of Physico-Chemical Biology, Moscow State University, Leninskye Gory, House 1, Building 40, 119992, Moscow, Russia; Center for Data-Intensive Biomedicine and Biotechnology, Skolkovo Institute of Science and Technology, 143028, Moscow, Russia. Electronic address: vtosha@yandex.ru.
Irina KuznetsovaDepartment of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkina St., 119991, Moscow, Russia. Electronic address: irakuzn@yahoo.com.
Peter Speranskiy-PodobedDepartment of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkina St., 119991, Moscow, Russia. Electronic address: ps.podobed@gmail.com.
Jane S BurnsEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA. Electronic address: jburns@hsph.harvard.edu.
Paige L WilliamsDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA. Electronic address: paige@sdac.harvard.edu.
Susan KorrickEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA. Electronic address: susan.korrick@channing.harvard.edu.
Mary M LeePediatric Endocrine Division, Department of Pediatrics, University of Massachusetts Medical School, 55 N Lake Avenue, Worcester, MA, 01655, USA. Electronic address: mary.lee@umassmemorial.org.
Evgeny RogaevDepartment of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkina St., 119991, Moscow, Russia; Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, 303 Belmont Street, 01604 Worcester, MA, USA. Electronic address: rogaev@vigg.ru.
Russ HauserEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA. Electronic address: rhauser@hsph.harvard.edu.
Oleg SergeyevDepartment of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkina St., 119991, Moscow, Russia; Chapaevsk Medical Association, 3a Meditsinskaya st., 446100, Chapaevsk, Samara region, Russia; A.N. Belozersky Research Institute of Physico-Chemical Biology, Moscow State University, Leninskye Gory, House 1, Building 40, 119992, Moscow, Russia. Electronic address: olegsergeyev1@yandex.ru.
Vavilov Institute of General Genetics · RUUniversity of Massachusetts Amherst · USHarvard University · USSkolkovo Institute of Science and Technology · RUUniversity of Massachusetts Chan Medical School · USBrigham and Women's Hospital · USNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation · RURussian Academy of Sciences · RUSamara State Medical University · RU

Funding

Effects of Environmental Phthalates and Chemical Mixtures on Male Puberty and Semen QualityR01ES014370 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HAUSER, RUSS B · 2006 to 2021
$8.2M
Phthalate Exposure, Sperm DNA Methylation and Early-life DevelopmentK22ES023085 · NIEHS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI PILSNER, J. RICHARD · 2014 to 2016
$441k
NIEHS NIH HHS K22 ES023085NIEHS NIH HHS R01 ES014370
6 · The paper itself

Abstract

backgroundThe association of exposure to endocrine disrupting chemicals in the peripubertal period with subsequent sperm DNA methylation is unknown.

objectiveWe examined the association of peripubertal serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) concentrations with whole-genome bisulfite sequencing (WGBS) of sperm collected in young adulthood.

methodsThe Russian Children's Study is a prospective cohort of 516 boys who were enrolled at 8-9 years of age and provided semen samples at 18-19 years of age. WGBS of sperm was conducted to identify differentially methylated regions (DMR) between highest (n = 4) and lowest (n = 4) peripubertal TCDD groups.

resultsWe found 52 DMRs that distinguished lowest and highest peripubertal serum TCDD concentrations. One of the top scoring networks, "Cellular Assembly and Organization, Cellular Function and Maintenance, Carbohydrate Metabolism", identified estrogen receptor alpha as its central regulator.

conclusionFindings from our limited sample size suggest that peripubertal environmental exposures are associated with sperm DNA methylation in young adults.

Indexed as

DNA MethylationAdolescentAdultChildEndocrine DisruptorsEnvironmental MonitoringEnvironmental PollutantsHumansMalePolychlorinated DibenzodioxinsPubertyRussiaSpermatozoaWhole Genome SequencingYoung AdultEndocrine DisruptorsEnvironmental PollutantsPolychlorinated DibenzodioxinsDNA methylationEndocrine disrupting chemicalsEnvironmental effectsPeripubertyRussian Children’s StudySperm methylomeSusceptible window of germ cell developmentWhole genome bisulfite sequencing

Identifiers

PMID29550351
PMCPMC6130911
OpenAlexW2793652739

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.