Evidence map›Paper›PMID 29549752›Full record

ArticleBehaviour research and therapy2018

Avoidance and escape: Defensive reactivity and trait anxiety.

Christopher T Sege, Margaret M Bradley, Peter J Lang

Open access · bronzeAbstract read
In one paragraph

Article in Behaviour research and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

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  7. Disentangling the Neural Circuits of Arousal and Anxiety-Like Behavior.Current topics in behavioral neurosciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christopher T SegeUniversity of Florida Center for the Study of Emotion and Attention, 3063 Longleaf Road, Gainesville, FL, 32608, United States. Electronic address: sege@musc.edu.
Margaret M BradleyUniversity of Florida Center for the Study of Emotion and Attention, 3063 Longleaf Road, Gainesville, FL, 32608, United States.
Peter J LangUniversity of Florida Center for the Study of Emotion and Attention, 3063 Longleaf Road, Gainesville, FL, 32608, United States.
University of Florida · US

Funding

Anxiety, comorbidity, negative affect, and fear circuit activationR01MH094386 · NIMH · UNIVERSITY OF FLORIDA · PI LANG, PETER J · 2012 to 2017
$1.8M
From Fear to Anxious Misery: Developing a Defense Circuit Dimensional ClassifierR01MH098078 · NIMH · UNIVERSITY OF FLORIDA · PI LANG, PETER J · 2012 to 2015
$1.7M
NIMH NIH HHS R01 MH094386NIMH NIH HHS R01 MH098078
6 · The paper itself

Abstract

Although avoidance and escape behaviors each contribute to maintaining anxiety disorders, only avoidance completely eliminates exposure to the aversive context. Current research compared anticipatory defensive engagement when aversion could either be completely avoided or escaped after initial exposure; in addition, this research examined the impact of trait anxiety on coping-related defensive engagement. Cues signaled that upcoming rapid action would avoid (block), escape (terminate), or not affect subsequent aversive exposure; the acoustic startle reflex was measured during each anticipatory interval to index defensive engagement, and blink magnitudes were compared across low-, moderate-, and high-anxious individuals. For all participants, startle was potentiated when aversive exposure was uncontrollable and attenuated when aversion was avoidable. On escape trials, on the other hand, startle potentiation increased with rising participant anxiety. Results suggest 1) defensive engagement is generally reduced in avoidance contexts relative to contexts in which exposure is certain, and; 2) trait anxiety increases defensive engagement specifically when aversive exposure can be controlled but remains certain.

Indexed as

AdolescentAnxietyAutonomic Nervous SystemFearFemaleGalvanic Skin ResponseHeart RateHumansMaleReaction TimeReflex, StartleYoung AdultAnxietyAvoidanceEscapeHeart rateSkin conductanceStartle reflex

Identifiers

PMID29549752
PMCPMC5903567
OpenAlexW2791147032

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.