ArticleInvestigational new drugs2018
The molecular mechanism of anticancer action of novel octahydropyrazino[2,1-a:5,4-a']diisoquinoline derivatives in human gastric cancer cells.
Article in Investigational new drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Antiproliferative activity of platinum(II) and copper(II) complexes containing novel biquinoxaline ligands.Metallomics : integrated biometal science · 2024Article
- Synthesis and Anticancer Activity of 1,3,4-Thiadiazoles with 3-Methoxyphenyl Substituent.Molecules (Basel, Switzerland) · 2022Article
- Design, Synthesis and Biological Evaluation of Neocryptolepine Derivatives as Potential Anti-Gastric Cancer Agents.International journal of molecular sciences · 2022Article
- Protective Effect of Methanolic Extract ofIndian journal of clinical biochemistry : IJCB · 2022Article
- 2-{5-[(International journal of molecular sciences · 2022Article
- Mucin 1 as a Molecular Target of a Novel Diisoquinoline Derivative Combined with Anti-MUC1 Antibody in AGS Gastric Cancer Cells.Molecules (Basel, Switzerland) · 2021Article
- Autophagy Modulators in Cancer Therapy.International journal of molecular sciences · 2021Review
- Mechanism of Anticancer Action of Novel Imidazole Platinum(II) Complex Conjugated with G2 PAMAM-OH Dendrimer in Breast Cancer Cells.International journal of molecular sciences · 2021Article
- The Anticancer Action of a Novel 1,2,4-Triazine Sulfonamide Derivative in Colon Cancer Cells.Molecules (Basel, Switzerland) · 2021Article
- The Effect of Novel 7-methyl-5-phenyl-pyrazolo[4,3-International journal of molecular sciences · 2020Article
- Targeting ROS overgeneration by N-benzyl-2-nitro-1-imidazole-acetamide as a potential therapeutic reposition approach for cancer therapy.Investigational new drugs · 2020Article
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Authors and funding
7 authors.
Funding
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Abstract
Objective The aim of the current study was to examine the anticancer activity and the detailed mechanism of novel diisoquinoline derivatives in human gastric cancer cells (AGS). Methods The viability of AGS cells was measured by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Cell cycle analysis and apoptosis assay were performed by standard flow cytometric method. Confocal microscopy bioimaging was used to demonstrate the expression of pivotal proteins engaged in apoptosis (caspase-8, caspase-3, p53) and cell signaling (AKT, ERK1/2). Results All compounds decreased the number of viable cells in a dose-dependent manner after 24 and 48 h of incubation, although compound 2 was a more cytotoxic agent, with IC
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