ArticleWorld journal of pediatrics : WJP2018
Elevated serum neopterin levels in children with functional constipation: association with systemic proinflammatory cytokines.
Article in World journal of pediatrics : WJP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Claudin-3 as a marker of intestinal permeability and its relation to inflammatory status in adolescents with functional gastrointestinal disorders.Pediatric research · 2026Article
- Bacillus spore probiotics for alleviating functional constipation in children: a randomized, double-blind, placebo-controlled trial.Communications medicine · 2026Article
- Clinical hallmarks and peripheral immune factors associated with antipsychotic-induced constipation in schizophrenia.Therapeutic advances in psychopharmacology · 2026Article
- Clinical Efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) in Pediatric Functional Constipation: Impact on Immunological Indicators and Gut Microbiota.Journal of immunology research · 2025Article
- Shaoyao Gancao decoction alleviates functional constipation by inhibitingFrontiers in cellular and infection microbiology · 2025Article
- Epidermal functions are associated with constipation in the elderly.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Intestinal microbiome changes and mechanisms of maintenance hemodialysis patients with constipation.Frontiers in cellular and infection microbiology · 2024Article
- Article
- Diet supporting therapy for inflammatory bowel diseases.European journal of nutrition · 2021Review
- Fecal Microbiota Transplantation Modulates the Gut Flora Favoring Patients With Functional Constipation.Frontiers in microbiology · 2021Article
- Constipation might be associated with risk of allergic rhinitis: A nationwide population-based cohort study.PloS one · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFunctional constipation is a clinical problem with an incompletely understood etiology. Functional bowel diseases have been shown to be related to inflammation in many studies in adults. In this study, we aimed to evaluate leukocytes, C-reactive protein, proinflammatory and anti-inflammatory cytokines, and neopterin levels in children with functional constipation.
methodsSeventy-six children with constipation and 71 healthy controls (mean age 7.12 ± 3.46 years and 7.32 ± 4.33 years, respectively, P = 0.991) were included in the study. Leukocytes, C-reactive protein, interleukin (IL)-1β, IL-6, IL-10, IL-12, tumor necrosis factor-alpha (TNF-α) and neopterin levels were assessed in patients and healthy controls. Parameters were measured in the serum using enzyme-linked immunosorbent assay methods.
resultsMean IL-6 (20.31 ± 12.05 vs. 16.2 ± 10.25 pg/mL, respectively, P = 0.003), IL-12 (181.42 ± 133.45 vs. 135.6 ± 83.67 pg/mL, respectively, P = 0.018) and neopterin levels (2.08 ± 1.12 vs. 1.52 ± 1.02 pg/mL, respectively, P = 0.001) were significantly higher in constipated children than healthy controls. Leukocyte and thrombocyte counts, C-reactive protein, and IL-1β, IL-10 and TNF-α levels did not show any difference between the two groups.
conclusionsIn this study, IL-6, IL-12 and neopterin levels of constipated patients were found to be higher than those of controls. These results indicate the presence of subclinical inflammation in children with functional constipation.
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