Evidence map›Paper›PMID 29549574›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2018

Clinical and Cost Implications of Insulin Degludec in Patients with Type 1 Diabetes and Problematic Hypoglycemia: A Quality Improvement Project.

Muhammad Ali Karamat, Shujah Dar, Srikanth Bellary, Abd A Tahrani

Abstract read
In one paragraph

Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Use of Degludec in Youth With Type 1 Diabetes and Recurrent Diabetic Ketoacidosis.Clinical diabetes : a publication of the American Diabetes Association · 2025
    Article
  2. Review
  3. Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Muhammad Ali KaramatDepartment of Diabetes and Endocrinology, Diabetes Centre, Heartlands Hospital, Birmingham, UK. muhammad.karamat@heartofengland.nhs.uk.ORCID http://orcid.org/0000-0001-9808-3841
Shujah DarDepartment of Diabetes and Endocrinology, Queen Elizabeth Hospital, Birmingham, UK.
Srikanth BellaryDepartment of Diabetes and Endocrinology, Diabetes Centre, Heartlands Hospital, Birmingham, UK.
Abd A TahraniDepartment of Diabetes and Endocrinology, Diabetes Centre, Heartlands Hospital, Birmingham, UK.

Funding

Department of Health CS-2013-13-029
6 · The paper itself

Abstract

introductionTo assess the real-life clinical benefits and cost implications of switching from another basal insulin to insulin degludec (degludec) in patients with type 1 diabetes (T1D) on basal-bolus regimens with recurrent hypoglycemia and/or hypoglycemia unawareness.

methodsPatients with T1D who were aged ≥ 18 years, were on a basal-bolus regimen, and had switched to degludec plus bolus insulin for at least 6 months were included. Patients had to have switched to degludec as a result of recurrent hypoglycemia and/or hypoglycemia unawareness.

resultsSix months of follow-up data were available for 42 patients. At 6 months, there was a significant reduction in median (interquartile range) HbA

conclusionIn patients with T1D, switching to degludec was associated with an improvement in HbA

fundingNovo Nordisk.

Indexed as

Healthcare deliveryHypoglycemiaInsulin degludecInsulin therapyType 1 diabetes

Identifiers

PMID29549574
PMCPMC6104283

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.