ArticleWorld journal of surgery2018
Changing Profile of Primary Hyperparathyroidism Over Two and Half Decades: A Study in Tertiary Referral Center of North India.
Article in World journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Primary hyperparathyroidism in developing world: a systematic review on the changing clinical profile of the disease.Archives of endocrinology and metabolism · 2020Pooled it
- Primary Hyperparathyroidism with Severe Vitamin D Deficiency in Chronic Kidney Disease.Internal medicine (Tokyo, Japan) · 2025Article
- Clinico-Pathological Study of Symptomatic Hyperparathyroidism: Is it a Different Phenotype Expression of Hyperparathyroidism?Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Characteristics, management and outcomes of primary hyperparathyroidism from 2009 to 2021: a single centre report from South Africa.BMC endocrine disorders · 2024Article
- Symptomatic versus asymptomatic primary hyperparathyroidism: A systematic review and meta-analysis.Journal of clinical & translational endocrinology · 2023Article
- Epidemiology, Pathophysiology, and Genetics of Primary Hyperparathyroidism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Review
- Primary hyperparathyroidism presenting as acute pancreatitis: An institutional experience with review of the literature.World journal of gastrointestinal pharmacology and therapeutics · 2022Article
- Pediatric Primary Hyperparathyroidism: Experience in a Tertiary Care Referral Center in a Developing Country Over Three Decades.World journal of surgery · 2021Article
- Primary Hyperparathyroidism.The Journal of clinical endocrinology and metabolism · 2018Review
- Primary Hyperparathyroidism: Clinical, Biochemical, and Radio-Pathological Profiles of 804 Patients - A Retrospective Study from South India.Indian journal of endocrinology and metabolismArticle
- PHPT with Pancreatitis: Atypical Presentation of PHPT.Indian journal of endocrinology and metabolismArticle
- Surgical Management of Primary Hyperparathyroidism in the Era of Focused Parathyroidectomy: A Study in Tertiary Referral Centre of North India.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost of the cases of PHPT in developing countries present in symptomatic stage, some even in very advanced stage but in recent years the trend seems to be changing. This has been corroborated from few recently published literature from developing countries. The scope of this study is to further carry out an in-depth analysis of various clinical and biochemical parameters of PHPT patients at a tertiary care center of northern India.
methodsIn this retrospective analysis, a total of 333 patients with PHPT from the year 1990 to 2016 were studied. The study population was divided into three subgroups based on the time span; 1990-1999 (n = 34), 2000-2009 (n = 112), 2010-2016 (n = 187), and clinical and biochemical parameters were compared.
resultsThe clinical presentation has evolved progressively with increase in older age group (35 vs 39 vs 43.85, p < 0.001), less patients with musculoskeletal symptoms (85.3 vs 76.8 vs 61%, p = 0.002) and less patients with severe bone disease (29.4 vs 10.7 vs 10.7%, p = 0.088). Biochemical parameters also showed a changing trend with significant decrease in mean S. Alkaline phosphatase (1393 vs 965 vs 414.8 IU/L, p < 0.001) and S. iPTH (837.52 vs 812.89 vs 635.74 pg/mL, p = 0.02). Vitamin D nutrition status is still suboptimal but shows improvement, and more patients are insufficient as compared to previous deficient state (mean S. Vitamin D-10.31 vs 16.16 vs 25.30 ng/mL, p < 0.001).
conclusionsOur study reveals a change in trend in PHPT which is similar to evolution of this disease in western population and positively corroborated with observations from China, Hong Kong and Turkey.
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