Evidence map›Paper›PMID 29549496›Full record

Trial reportEuropean journal of nutrition2019

Exploring the association between whole blood Omega-3 Index, DHA, EPA, DHA, AA and n-6 DPA, and depression and self-esteem in adolescents of lower general secondary education.

I S M van der Wurff, C von Schacky, T Bergeland, R Leontjevas, M P Zeegers, P A Kirschner, R H M de Groot

Erratum issuedOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Mental health in society's margins: poorThe British journal of nutrition · 2024
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 5 countries.

I S M van der WurffWelten Institute, Research Centre for Learning, Teaching, and Technology, Open University of the Netherlands, Valkenburgerweg 177, P.O. Box 2960, 6419 AT, Heerlen, The Netherlands. inge.vanderwurff@ou.nl.
C von SchackyOmegametrix, 82 152, Martinsried, Germany.
T BergelandAker BioMarine Antarctic AS, 1327, Lysaker, Norway.
R LeontjevasFaculty of Psychology and Educational Sciences, Open University of the Netherlands, 6419 AT, Heerlen, The Netherlands.
M P ZeegersNutrition and Translational Research in Metabolism (School NUTRIM), Maastricht University, 6200 MD, Maastricht, The Netherlands.
P A KirschnerWelten Institute, Research Centre for Learning, Teaching, and Technology, Open University of the Netherlands, Valkenburgerweg 177, P.O. Box 2960, 6419 AT, Heerlen, The Netherlands.
R H M de GrootWelten Institute, Research Centre for Learning, Teaching, and Technology, Open University of the Netherlands, Valkenburgerweg 177, P.O. Box 2960, 6419 AT, Heerlen, The Netherlands.
Open University of the Netherlands · NLBioMar (Norway) · NODepartment of Health · TWLudwig-Maximilians-Universität München · DEMaastricht University · NL

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NL) 057-13-002
6 · The paper itself

Abstract

purposeDepression is common in adolescents and long-chain polyunsaturated fatty acids (LCPUFA) are suggested to be associated with depression. However, research in adolescents is limited. Furthermore, self-esteem has never been studied in relation to LCPUFA. The objective here was to determine associations of depression and self-esteem with eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), Omega-3 Index (O3I), n-6 docosapentaenoic acid (n-6 DPA, also called Osbond acid, ObA), n-3 docosapentaenoic acid (DPA), and arachidonic acid (AA) concentrations in blood of adolescents attending lower general secondary education (LGSE).

methodsBaseline cross-sectional data from a krill oil supplementation trial in adolescents attending LGSE with an O3I ≤ 5% were analysed using regression models built with the BayesFactor package in R. Fatty acids and O3I were determined in blood. Participants filled out the Centre for Epidemiologic Studies Depression (CES-D) scale and the Rosenberg Self-Esteem scale (RSE).

resultsScores indicative of depression (CES-D ≥ 16) were found in 29.4% of the respondents. Of all fatty acids, we found extreme evidence [Bayes factor (BF) > 100] for a weak negative association between ObA and depression score [- 0.16; 95% credible interval (CI) - 0.28 to - 0.04; BF

conclusionNo evidence was found for associations of DHA, EPA and O3I with depression or self-esteem scores in LGSE adolescents with O3I ≤ 5%. The associations of higher ObA status with lower depression and higher self-esteem scores warrant more research.

Indexed as

Self ConceptAdolescentAnimalsArachidonic AcidCross-Sectional StudiesDepressive DisorderDietary SupplementsDocosahexaenoic AcidsDouble-Blind MethodEicosapentaenoic AcidEuphausiaceaFatty Acids, Omega-3Fatty Acids, UnsaturatedFemaleFish OilsHumansArachidonic AcidDocosahexaenoic Acidsdocosapentaenoic acidEicosapentaenoic AcidFatty Acids, Omega-3Fatty Acids, UnsaturatedFish OilsAdolescentsBrain functioningDepressed moodHealthy youthHigh schoolersLong-chain polyunsaturated fatty acidOmega-3 IndexSelf-esteem

Identifiers

PMID29549496
PMCPMC6561989
OpenAlexW2790540795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.