Evidence map›Paper›PMID 29549333›Full record

ArticleScientific reports2018

Bat-mouse bone marrow chimera: a novel animal model for dissecting the uniqueness of the bat immune system.

Kylie Su Mei Yong, Justin Han Jia Ng, Zhisheng Her, Ying Ying Hey, Sue Yee Tan, Wilson Wei Sheng Tan, Sergio Erdal Irac, Min Liu, Xue Ying Chan, Merry Gunawan and 7 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Establishment of a Captive Cave Nectar Bat (Journal of the American Association for Laboratory Animal Science : JAALAS · 2022
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Animal Models to Study Emerging Technologies Against SARS-CoV-2.Cellular and molecular bioengineering · 2020
    Article
  11. Novel Insights Into Immune Systems of Bats.Frontiers in immunology · 2020
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Kylie Su Mei YongInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 138673, Singapore, Singapore.
Justin Han Jia NgProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore, Singapore.ORCID 0000-0002-1076-6013
Zhisheng HerInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 138673, Singapore, Singapore.
Ying Ying HeyProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore, Singapore.
Sue Yee TanInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 138673, Singapore, Singapore.
Wilson Wei Sheng TanInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 138673, Singapore, Singapore.
Sergio Erdal IracProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore, Singapore.
Min LiuInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 138673, Singapore, Singapore.
Xue Ying ChanInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 138673, Singapore, Singapore.ORCID 0000-0002-1685-0531
Merry GunawanInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 138673, Singapore, Singapore.
Randy Jee Hiang FooProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore, Singapore.
Dolyce Hong Wen LowProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore, Singapore.ORCID 0000-0003-4399-7325
Ian Hewitt MendenhallProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore, Singapore.
Yok Teng ChionhProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore, Singapore.
Charles-Antoine DutertreProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore, Singapore.
Qingfeng ChenInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 138673, Singapore, Singapore. qchen@imcb.a-star.edu.sg.
Lin-Fa WangProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore, Singapore. linfa.wang@duke-nus.edu.sg.ORCID 0000-0003-2752-0535
Agency for Science, Technology and Research · SGDuke-NUS Medical School · SGSingapore Immunology Network · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bats are an important animal model with long lifespans, low incidences of tumorigenesis and an ability to asymptomatically harbour pathogens. Currently, in vivo studies of bats are hampered due to their low reproduction rates. To overcome this, we transplanted bat cells from bone marrow (BM) and spleen into an immunodeficient mouse strain NOD-scid IL-2R

Indexed as

AnimalsBone Marrow TransplantationChiropteraGraft RejectionGraft SurvivalLymphocytesMiceMice, Inbred NODMice, SCIDSevere Combined ImmunodeficiencyTransplantation Chimera

Identifiers

PMID29549333
PMCPMC5856848
OpenAlexW2807304188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.