ArticleNature communications2018
Scalable total synthesis and comprehensive structure-activity relationship studies of the phytotoxin coronatine.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed.
- Borylcyclopropanes: Synthetic Strategies and Applications.Angewandte Chemie (International ed. in English) · 2026Review
- LC-MS and High-Throughput Data Processing Solutions for Lipid Metabolic Tracing Using Bioorthogonal Click Chemistry.Angewandte Chemie (International ed. in English) · 2025Article
- A Modular and Scalable Route to Protected Cyclopropane Amino Acid Building Blocks.Organic letters · 2025Article
- Discovery of type II polyketide synthase-like enzymes for the biosynthesis of cispentacin.Nature communications · 2023Article
- Investigations into Simplified Analogues of the Herbicidal Natural Product (+)-Cornexistin.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Subtype-selective agonists of plant hormone co-receptor COI1-JAZs identified from the stereoisomers of coronatine.Communications biology · 2023Article
- Exploring the interaction mechanism between antagonist and the jasmonate receptor complex by molecular dynamics simulation.Journal of computer-aided molecular design · 2022Article
- Article
- Stereoselective Syntheses of all the Possible Stereoisomers of Coronafacic Acid.ChemistryOpen · 2020Article
- Recent Advances in Plant Chemical Biology of Jasmonates.International journal of molecular sciences · 2020Review
- Gene Expression Profiles Deciphering the Pathways of Coronatine Alleviating Water Stress in Rice (International journal of molecular sciences · 2019Article
- A comprehensiveThe Journal of biological chemistry · 2019Article
- Jasmonates: News on Occurrence, Biosynthesis, Metabolism and Action of an Ancient Group of Signaling Compounds.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural phytotoxins are valuable starting points for agrochemical design. Acting as a jasmonate agonist, coronatine represents an attractive herbicidal lead with novel mode of action, and has been an important synthetic target for agrochemical development. However, both restricted access to quantities of coronatine and a lack of a suitably scalable and flexible synthetic approach to its constituent natural product components, coronafacic and coronamic acids, has frustrated development of this target. Here, we report gram-scale production of coronafacic acid that allows a comprehensive structure-activity relationship study of this target. Biological assessment of a >120 member library combined with computational studies have revealed the key determinants of potency, rationalising hypotheses held for decades, and allowing future rational design of new herbicidal leads based on this template.
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