Observational studyScientific reports2018
Risk of major adverse cardiovascular events in subjects with asymptomatic mild carotid artery stenosis.
Observational study in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Proteomics reveals spatial and molecular heterogeneities in advanced atherosclerotic carotid artery plaques.Nature cardiovascular research · 2026Article
- Retinal Dysfunction in Hypertensive Patients with Atherosclerotic Plaque Detected by Carotid Doppler Ultrasound: An Optical Coherence Tomography Angiography Assessment.Life (Basel, Switzerland) · 2026Article
- The Relevance of Optical Coherence Tomography Angiography in Screening and Monitoring Hypertensive Patients with Carotid Artery Stenosis.Diagnostics (Basel, Switzerland) · 2025Article
- Observational
- Common Carotid Artery Stenosis Degree as a Predictor of Cardiovascular Disease in a General Population: The Suita Study.Journal of the American Heart Association · 2024Article
- Retinal Microvascular Changes in Internal Carotid Artery Stenosis.Journal of clinical medicine · 2023Article
- Validity and Reliability of Point-of-Care Ultrasound for Detecting Moderate- or High-Grade Carotid Atherosclerosis in an Outpatient Department.Diagnostics (Basel, Switzerland) · 2023Article
- Characteristics of peripheral blood cells are independently related to major adverse cardiovascular events after carotid endarterectomy.Atherosclerosis plus · 2023Article
- Nomogram and Carotid Risk Score for Predicting Moderate or High Carotid Atherosclerosis among Asymptomatic Elderly Recycling Volunteers.Diagnostics (Basel, Switzerland) · 2022Article
- Cardiovascular risk scores in asymptomatic carotid stenosis: A validation study with ultrasonographic parameters.PloS one · 2022Article
- Carotid Plaque Composition Assessed by CT Predicts Subsequent Cardiovascular Events among Subjects with Carotid Stenosis.AJNR. American journal of neuroradiology · 2021Article
- Expression of miRNAs Targeting ATP Binding Cassette Transporter 1 (ABCA1) among Patients with Significant Carotid Artery Stenosis.Biomedicines · 2021Article
- Duplex ultrasound findings and clinical outcomes of carotid restenosis after carotid endarterectomy.PloS one · 2020Observational
- Effect of severe contralateral carotid stenosis or occlusion on early and late outcomes after carotid endarterectomy.Annals of surgical treatment and research · 2019Article
- A low-cost machine learning-based cardiovascular/stroke risk assessment system: integration of conventional factors with image phenotypes.Cardiovascular diagnosis and therapy · 2019Article
- Comparison of outcomes after carotid endarterectomy between type 2 diabetic and non-diabetic patients with significant carotid stenosis.Cardiovascular diabetology · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to test the hypothesis that the risk of major adverse cardiovascular events (MACE) is similar for subjects with asymptomatic mild and moderate carotid artery stenosis (CAS). We enrolled a total of 453 subjects with asymptomatic CAS (30-69%) detected on baseline screening Doppler ultrasound (DUS) examination between January 2008 and December 2010. The follow-up DUS findings and MACE occurrence (fatal or nonfatal myocardial infarction or stroke and all-cause mortality) were compared between subjects with mild (30-49%) and moderate (50-69%) CAS during the 8-year follow-up period. There was no significant difference in the occurrence of MACE between subjects with mild (n = 289) and moderate (n = 164) CAS (13.8% vs. 15.9%, respectively; p = 0.56), although there was a nonsignificant trend toward an increased risk of major ipsilateral stroke in subjects with moderate CAS (1.4% vs. 4.3%; p = 0.06). Multivariate regression analysis indicated that worsening CAS was independently associated with MACE occurrence (hazard ratio [HR], 4.40; 95% confidence interval [CI], 2.65-7.27; p < 0.01), whereas an increased serum high-density lipoprotein cholesterol level was correlated with a decreased risk of MACE (HR, 0.42; 95% CI, 0.23-0.75; p < 0.01). The cumulative risk of MACE in subjects with asymptomatic mild CAS is similar to that in subjects with asymptomatic moderate CAS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.