ArticleCell death & disease2018
Astrocytic metabolic switch is a novel etiology for Cocaine and HIV-1 Tat-mediated neurotoxicity.
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Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
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Who cites it
44 citing papers in PubMed, 61 citations in OpenAlex.
- Transcellular mitochondrial transfer from hypermetabolic astrocytes to neurons during cocaine and HIV-1 exposure.Cell communication and signaling : CCS · 2025Article
- Caloric restriction mimetic 2-deoxyglucose alters metabolic and transcriptomic phenotype in association with changes in chromatin accessibility in human astrocytes.Scientific reports · 2025Article
- Mitochondrial Calcium Uniporter (MCU)-Mediated Calcium Overload in Psychoactive Drug Neurotoxicity: From Pathogenesis to Therapeutic Targets.International journal of molecular sciences · 2025Review
- Article
- Cell-specific expression of key mitochondrial enzymes limits OXPHOS in astrocytes of the adult human neocortex and hippocampal formation.Communications biology · 2024Article
- HIV-1 and methamphetamine co-treatment in primary human astrocytes: TAARgeting ER/UPR dysfunction.NeuroImmune pharmacology and therapeutics · 2024Article
- Sera from people with HIV and depression induce commensurate metabolic alterations in astrocytes: toward precision diagnoses and therapies.NeuroImmune pharmacology and therapeutics · 2024Article
- Molecular Mechanisms Associated with Neurodegeneration of Neurotropic Viral Infection.Molecular neurobiology · 2024Review
- Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation.Communications biology · 2024Article
- Spatial Heterogeneity of Brain Lipids in SIV-Infected Macaques Treated with Antiretroviral Therapy.Journal of the American Society for Mass Spectrometry · 2024Article
- Disruption of blood-brain barrier: effects of HIV Tat on brain microvascular endothelial cells and tight junction proteins.Journal of neurovirology · 2023Review
- Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management.Nature reviews. Neurology · 2023Review
- Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation.Research square · 2023Article
- Single nucleotide polymorphisms in aquaporin-4 associate with cognitive impairment status in people with HIV.Journal of neurovirology · 2023Article
- Astrocytes: Role in pathogenesis and effect of commonly misused drugs in the HIV infected brain.Current research in neurobiology · 2023Review
- Review
- The Epigenetic Role of miR-124 in HIV-1 Tat- and Cocaine-Mediated Microglial Activation.International journal of molecular sciences · 2022Article
- Citrate shuttling in astrocytes is required for processing cocaine-induced neuron-derived excess peroxidated fatty acids.iScience · 2022Article
- Modulation of OPRM1 Alternative Splicing by Morphine and HIV-1 Nef.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2022Article
- HIV Tat and cocaine interactively alter genome-wide DNA methylation and gene expression and exacerbate learning and memory impairments.Cell reports · 2022Article
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Authors and funding
9 authors at 1 institution in 1 country.
Kalimuthusamy NatarajaseenivasanDepartment of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Bianca CottoDepartment of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Santhanam ShanmughapriyaDepartment of Medical Genetics and Molecular Biochemistry and the Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Alyssa A LombardiCenter for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine at Temple University, 3500 N Broad Street, Philadelphia, PA, USA.
Prasun K DattaDepartment of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Muniswamy MadeshDepartment of Medical Genetics and Molecular Biochemistry and the Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
John W ElrodCenter for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine at Temple University, 3500 N Broad Street, Philadelphia, PA, USA.
Kamel KhaliliDepartment of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Dianne LangfordDepartment of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. tdl@temple.edu.
Temple University · US
Funding
Project 3 Dysregulation of metabolic communication of oligodendrocytes and neurons by cocaine and TatP01DA037830 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI KHALILI, KAMEL · 2015 to 2019
$7.4MInterdisciplinary And Translational Research Training In NeurohivT32MH079785 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI Kamel Khalili · 2008 to 2026
$5.4MCoordination of Pathophysiologic Endothelial Cell Signaling by ROSR01HL086699 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2008 to 2018
$4.3MSpectral revelations of mitochondrial Ca2+ flux interactomeR01GM109882 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2014 to 2022
$3.3MMolecular composition of the mitochondrial calcium uniporter and cardiac pathophysiologyR01HL142271 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI ELROD, JOHN WILLIAM, HAJNOCZKY, GYORGY · 2018 to 2021
$3.0MMechanisms of mitochondrial calcium exchange in heart failureR01HL123966 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2014 to 2018
$2.3MPINCH-mediated CNS cell dysfunction and tauopathy in HIVR01MH107340 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI LANGFORD, DIANNE TERESA · 2016 to 2020
$2.0MNovel Molecular Mechanisms of Programmed NecrosisR01HL136954 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2017 to 2020
$1.6MInhibition of MCUR1-MCU mediated mitochondrial Ca2+ uptake prevents I/R injuryR01HL119306 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI MUNISWAMY, MADESH · 2014 to 2017
$1.6MMolecular link between MCU and Mrs2p channels for mitochondrial ion homeostasis and energy metabolismR00HL138268 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SANTHANAM, SHANMUGHAPRIYA · 2019 to 2021
$747kMultiphoton upgrade of confocal microscope for live organ and tissue imagingS10RR022511 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI MUNISWAMY, MADESH · 2007 to 2007
$500kROS-dependent STIM1 activation and Ca2+ entry in lung inflammationR21HL109920 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI MUNISWAMY, MADESH, SOBOLOFF, JONATHAN A · 2011 to 2012
$421kNCRR NIH HHS S10 RR022511NHLBI NIH HHS K99 HL138268NHLBI NIH HHS R00 HL138268NHLBI NIH HHS R01 HL086699NHLBI NIH HHS R01 HL119306NHLBI NIH HHS R01 HL123966NHLBI NIH HHS R01 HL136954NHLBI NIH HHS R01 HL142271NHLBI NIH HHS R21 HL109920NIDA NIH HHS P01 DA037830NIGMS NIH HHS R01 GM109882NIMH NIH HHS R01 MH107340NIMH NIH HHS T32 MH079785
Abstract
Calcium (Ca
Indexed as
AstrocytesCalciumCalcium ChannelsCells, CulturedCocaineFatty AcidsGlucoseHIV-1HumansLactic AcidLipid PeroxidationMembrane Potential, MitochondrialMitochondriaNeuronsReactive Oxygen SpeciesRecombinant ProteinsCalciumCalcium ChannelsCocaineFatty AcidsGlucoseLactic Acidmitochondrial calcium uniporterReactive Oxygen SpeciesRecombinant ProteinsRNA, Small Interferingtat Gene Products, Human Immunodeficiency Virus
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