Evidence map›Paper›PMID 29549220›Full record

ArticleNeurology2018

The state of clinical research in neurology.

Deborah A Hall, Alberto R Ramos, Jeffrey Marc Gelfand, Aleksander Videnovic, Michael Benatar, Carolyn Cahill, Benzi M Kluger, Myla Goldman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Deborah A HallFrom the Department of Neurological Sciences (D.H.), Rush University, Chicago, IL; Department of Neurology (A.R.R., M.B.), University of Miami, FL; Department of Neurology (J.M.G.), University of California San Francisco; Massachusetts General Hospital (A.V.), Boston; Member Insights Department (C.C.), American Academy of Neurology, Minneapolis, MN; Department of Neurology (B.M.K.), University of Colorado, Denver; and Department of Neurology (M.G.), University of Virginia, Charlottesville. Deborah_A_Hall@rush.edu.
Alberto R RamosFrom the Department of Neurological Sciences (D.H.), Rush University, Chicago, IL; Department of Neurology (A.R.R., M.B.), University of Miami, FL; Department of Neurology (J.M.G.), University of California San Francisco; Massachusetts General Hospital (A.V.), Boston; Member Insights Department (C.C.), American Academy of Neurology, Minneapolis, MN; Department of Neurology (B.M.K.), University of Colorado, Denver; and Department of Neurology (M.G.), University of Virginia, Charlottesville.
Jeffrey Marc GelfandFrom the Department of Neurological Sciences (D.H.), Rush University, Chicago, IL; Department of Neurology (A.R.R., M.B.), University of Miami, FL; Department of Neurology (J.M.G.), University of California San Francisco; Massachusetts General Hospital (A.V.), Boston; Member Insights Department (C.C.), American Academy of Neurology, Minneapolis, MN; Department of Neurology (B.M.K.), University of Colorado, Denver; and Department of Neurology (M.G.), University of Virginia, Charlottesville.
Aleksander VidenovicFrom the Department of Neurological Sciences (D.H.), Rush University, Chicago, IL; Department of Neurology (A.R.R., M.B.), University of Miami, FL; Department of Neurology (J.M.G.), University of California San Francisco; Massachusetts General Hospital (A.V.), Boston; Member Insights Department (C.C.), American Academy of Neurology, Minneapolis, MN; Department of Neurology (B.M.K.), University of Colorado, Denver; and Department of Neurology (M.G.), University of Virginia, Charlottesville.
Michael BenatarFrom the Department of Neurological Sciences (D.H.), Rush University, Chicago, IL; Department of Neurology (A.R.R., M.B.), University of Miami, FL; Department of Neurology (J.M.G.), University of California San Francisco; Massachusetts General Hospital (A.V.), Boston; Member Insights Department (C.C.), American Academy of Neurology, Minneapolis, MN; Department of Neurology (B.M.K.), University of Colorado, Denver; and Department of Neurology (M.G.), University of Virginia, Charlottesville.
Carolyn CahillFrom the Department of Neurological Sciences (D.H.), Rush University, Chicago, IL; Department of Neurology (A.R.R., M.B.), University of Miami, FL; Department of Neurology (J.M.G.), University of California San Francisco; Massachusetts General Hospital (A.V.), Boston; Member Insights Department (C.C.), American Academy of Neurology, Minneapolis, MN; Department of Neurology (B.M.K.), University of Colorado, Denver; and Department of Neurology (M.G.), University of Virginia, Charlottesville.
Benzi M KlugerFrom the Department of Neurological Sciences (D.H.), Rush University, Chicago, IL; Department of Neurology (A.R.R., M.B.), University of Miami, FL; Department of Neurology (J.M.G.), University of California San Francisco; Massachusetts General Hospital (A.V.), Boston; Member Insights Department (C.C.), American Academy of Neurology, Minneapolis, MN; Department of Neurology (B.M.K.), University of Colorado, Denver; and Department of Neurology (M.G.), University of Virginia, Charlottesville.
Myla GoldmanFrom the Department of Neurological Sciences (D.H.), Rush University, Chicago, IL; Department of Neurology (A.R.R., M.B.), University of Miami, FL; Department of Neurology (J.M.G.), University of California San Francisco; Massachusetts General Hospital (A.V.), Boston; Member Insights Department (C.C.), American Academy of Neurology, Minneapolis, MN; Department of Neurology (B.M.K.), University of Colorado, Denver; and Department of Neurology (M.G.), University of Virginia, Charlottesville.

Funding

Exploring Sleep in Neurocognitive Aging and Alzheimer's Research (eSANAR)R21AG056952 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RAMOS, ALBERTO RAFAEL · 2017 to 2018
$411k
Sleep Apnea Phenotypes in Latinos (SLEPT)R21HL140437 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RAMOS, ALBERTO RAFAEL · 2019 to 2020
$258k
NHLBI NIH HHS R21 HL140437NIA NIH HHS R21 AG056952
6 · The paper itself

Abstract

objectiveTo study and provide an update on the state of clinical research in neurology in the United States.

methodsUS American Academy of Neurology members and chairs of departments of neurology were surveyed regarding clinical research in 2016. NIH data on the neuroscience pipeline and extramural grant funding were also collected.

resultsThe response rate was 32% (n = 254) for nonchair researchers and 58% (n = 67) for department chairs. Researcher respondents were on average 50 years old, 66% were men, and 81% were actively conducting clinical research, with phase II/III clinical trials and outcome measure studies being the most common type of research conducted. Time to conduct research, recruitment, and administrative burden were the major barriers reported. According to department chairs, funding and training opportunities in patient-oriented research have increased over the last 10 years. Overall, applicants to neuroscience-specific NIH institutes for extramural funding have decreased over the same time period.

conclusionsThe state of clinical research in neurology has remained relatively stable over the last 10 years, but neurologists still have barriers in conducting clinical research. There has been an interval decrease in neuroscience applicants for NIH funding, which raises concerns about the pipeline and future of clinical research in neurology. These results will serve as a reference for the development of solutions to these issues.

Indexed as

Biomedical ResearchNeurologyClinical Trials as TopicFemaleHumansMaleMiddle AgedSocieties, MedicalUnited States

Identifiers

PMID29549220
PMCPMC5894931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.