Evidence map›Paper›PMID 29549179›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Different Selected Mechanisms Attenuated the Inhibitory Interaction of KIR2DL1 with C2

Neda Nemat-Gorgani, Hugo G Hilton, Brenna M Henn, Meng Lin, Christopher R Gignoux, Justin W Myrick, Cedric J Werely, Julie M Granka, Marlo Möller, Eileen G Hoal and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Frontiers in genetics · 2025
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  12. Following Transplantation for Acute Myelogenous Leukemia, DonorJournal of immunology (Baltimore, Md. : 1950) · 2021
    Article
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  16. Single Nucleotide Polymorphism inFrontiers in immunology · 2020
    Article
  17. Article
  18. Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 5 countries.

Neda Nemat-GorganiDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.
Hugo G HiltonDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-1488-7194
Brenna M HennDepartment of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794.ORCID 0000-0003-4998-287X
Meng LinDepartment of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794.
Christopher R GignouxColorado Center for Personalized Medicine, University of Colorado, Denver, CO 80045.
Justin W MyrickDepartment of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794.
Cedric J WerelySouth African Medical Research Council Centre for Tuberculosis Research, Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa.
Julie M GrankaDepartment of Biology, Stanford University, Stanford, CA 94305.
Marlo MöllerSouth African Medical Research Council Centre for Tuberculosis Research, Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa.ORCID 0000-0002-0805-6741
Eileen G HoalSouth African Medical Research Council Centre for Tuberculosis Research, Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa.ORCID 0000-0002-6444-5688
Makoto YawataDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.
Nobuyo YawataDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-3537-6097
Lies BoelenSection of Immunology, Imperial College London, London SW7 2BX, United Kingdom.
Becca AsquithSection of Immunology, Imperial College London, London SW7 2BX, United Kingdom.ORCID 0000-0002-5911-3160
Peter ParhamDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.
Paul J NormanDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305; paul.norman@stanford.edu.ORCID 0000-0001-8370-7703
Stanford University · USSouth African Medical Research Council · ZAStony Brook University · USImperial College London · GBAgency for Science, Technology and Research · SGFukuoka Dental College · JPUniversity of Colorado Denver · US

Funding

Insights Into Immune-Related Diseases Born from Population GenomicsU01AI090905 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Paul John Norman · 2010 to 2026
$10.9M
KIR association studies in neurological diseasesU19NS095774 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERNANDEZ-VINA, MARCELO, OKSENBERG, JORGE R. · 2015 to 2019
$7.0M
STRUCTURAL BIOLOGY OF HLA-A,B ANTIGENSR01AI017892 · NIAID · STANFORD UNIVERSITY · PI PARHAM, PETER R · 1985 to 2019
$6.1M
Medical Research Council G0601072Medical Research Council MR/J007439/1NIAID NIH HHS R01 AI017892NIAID NIH HHS U01 AI090905NINDS NIH HHS U19 NS095774
6 · The paper itself

Abstract

The functions of human NK cells in defense against pathogens and placental development during reproduction are modulated by interactions of killer cell Ig-like receptors (KIRs) with HLA-A, -B and -C class I ligands. Both receptors and ligands are highly polymorphic and exhibit extensive differences between human populations. Indigenous to southern Africa are the KhoeSan, the most ancient group of modern human populations, who have highest genomic diversity worldwide. We studied two KhoeSan populations, the Nama pastoralists and the ≠Khomani San hunter-gatherers. Comprehensive next-generation sequence analysis of

Indexed as

Africa, SouthernFemaleGenes, MHC Class IHaplotypesHLA-C AntigensHumansKiller Cells, NaturalLigandsMalePolymorphism, GeneticReceptors, KIRReceptors, KIR2DL1Receptors, Natural Killer CellSelection, GeneticHLA-C AntigensKIR2DL1 protein, humanLigandsReceptors, KIRReceptors, KIR2DL1Receptors, Natural Killer Cell

Identifiers

PMID29549179
PMCPMC5990024
OpenAlexW2791506787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.