ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018
A Novel TGFβ Trap Blocks Chemotherapeutics-Induced TGFβ1 Signaling and Enhances Their Anticancer Activity in Gynecologic Cancers.
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Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 65 citations in OpenAlex.
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- A positive feedback loop between SERPINH1 and MMP-9/TGF-β1 promotes lung adenocarcinoma progression.Cell death and differentiation · 2026Article
- Signaling networks and MiRNA crosstalk in ovarian cancer chemoresistance.Journal of ovarian research · 2025Review
- GPX3 promotes cisplatin resistance in TNBC by manipulating ROS-TGFB1-ZEB2.Cell communication and signaling : CCS · 2025Article
- Th1 differentiation and function are inhibited in neonates following human metapneumovirus infection.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Co-targeting TGF-β and PD-L1 sensitizes triple-negative breast cancer to experimental immunogenic cisplatin-eribulin chemotherapy doublet.The Journal of clinical investigation · 2025Article
- USP9X integrates TGF-β and hypoxia signalings to promote ovarian cancer chemoresistance via HIF-2α-maintained stemness.Cell death & disease · 2025Article
- Evaluating TGF-β1 gene expression and promoter polymorphism in cervical cancer progression.Journal of molecular histology · 2025Article
- Fibrotic extracellular matrix preferentially induces a partial Epithelial-Mesenchymal Transition phenotype in a 3-D agent based model of fibrosis.Mathematical biosciences · 2025Article
- Engineered multifunctional transforming growth factor-β type II receptor ectodomain fusions for oncology applications.Frontiers in oncology · 2025Article
- Optimizing Scalp Cooling: (Ultra)Structural Follicular Characteristic and Restorative Advances.Cancer management and research · 2025Article
- PKM2-Driven Lactate Overproduction Triggers Endothelial-To-Mesenchymal Transition in Ischemic Flap via Mediating TWIST1 Lactylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Extracellular vesicles in cancers: mechanisms, biomarkers, and therapeutic strategies.MedComm · 2024Review
- Circulating serum miRNAs predict response to platinum chemotherapy in high-grade serous ovarian cancer.Cancer medicine · 2024Article
- Multicompartmentalized Microvascularized Tumor-on-a-Chip to Study Tumor-Stroma Interactions and Drug Resistance in Ovarian Cancer.Cellular and molecular bioengineering · 2024Article
- Drug resistance mechanisms and treatment strategies mediated by Ubiquitin-Specific Proteases (USPs) in cancers: new directions and therapeutic options.Molecular cancer · 2024Review
- Advances and Challenges in Targeting TGF-β Isoforms for Therapeutic Intervention of Cancer: A Mechanism-Based Perspective.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Transcriptome analysis reveals the clinical significance of CXCL13 in Pan-Gyn tumors.Journal of cancer research and clinical oncology · 2024Article
- Protein cargo in extracellular vesicles as the key mediator in the progression of cancer.Cell communication and signaling : CCS · 2024Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Haiyan ZhuDepartment of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xiang GuDepartment of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, Texas.
Lu XiaDepartment of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, Texas.
You ZhouDepartment of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, Texas.
Hakim BouamarDepartment of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, Texas.
Junhua YangDepartment of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, Texas.
Xiaofei DingDepartment of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, Texas.
Christian ZwiebDepartment of Biochemistry, University of Texas Health Science Center at San Antonio, Texas.
Jianan ZhangDepartment of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Andrew P HinckDepartment of Biochemistry, University of Texas Health Science Center at San Antonio, Texas.
Lu-Zhe SunDepartment of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. sunl@uthscsa.edu zjwzzxq@163.com.
Xueqiong ZhuDepartment of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. sunl@uthscsa.edu zjwzzxq@163.com.
The University of Texas Health Science Center at San Antonio · USWenzhou Medical University · CNCentral South University · CN
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1MLIGAND/RECEPTOR INTERACTIONS IN THE TGF BETA SUPERFAMILYR01GM058670 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HINCK, ANDREW P · 1999 to 2017
$3.6MInhibition of the tumor-promoting effects of TGF-beta in advanced prostate cancerR01CA172886 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HINCK, ANDREW P, SUN, LUZHE · 2013 to 2016
$1.2MNCI NIH HHS P30 CA054174NCI NIH HHS R01 CA172886NIGMS NIH HHS R01 GM058670
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsAntineoplastic AgentsCell Line, TumorCell MovementDisease Models, AnimalEpithelial-Mesenchymal TransitionFemaleGene Expression ProfilingGenital Neoplasms, FemaleHumansMiceNeoplasm StagingNeoplastic Stem CellsPhosphorylationSignal TransductionSmad2 ProteinAntineoplastic AgentsSmad2 ProteinSMAD2 protein, humanSmad3 ProteinSMAD3 protein, humanTGFB1 protein, humanTransforming Growth Factor betaTransforming Growth Factor beta1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.