Evidence map›Paper›PMID 29549102›Full record

ArticleApplied and environmental microbiology2018

Chimeric Fatty Acyl-Acyl Carrier Protein Thioesterases Provide Mechanistic Insight into Enzyme Specificity and Expression.

Marika Ziesack, Nathan Rollins, Aashna Shah, Brendon Dusel, Gordon Webster, Pamela A Silver, Jeffrey C Way

Open access · bronzeAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Heterologous Expression ofInternational journal of molecular sciences · 2022
    Article
  7. Thioesterase enzyme families: Functions, structures, and mechanisms.Protein science : a publication of the Protein Society · 2022
    Article
  8. Review
  9. Highly Active CACS synthetic biology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Marika Ziesack *Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, Massachusetts, USA marika.ziesack@googlemail.com jeff.way@wyss.harvard.edu.ORCID 0000-0003-0587-6581
Nathan Rollins *Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, Massachusetts, USA.
Aashna ShahWyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, Massachusetts, USA.
Brendon DuselWyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, Massachusetts, USA.
Gordon WebsterWyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, Massachusetts, USA.
Pamela A SilverWyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, Massachusetts, USA.
Jeffrey C WayWyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, Massachusetts, USA marika.ziesack@googlemail.com jeff.way@wyss.harvard.edu.
Harvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medium-chain fatty acids are commodity chemicals. Increasing and modifying the activity of thioesterases (TEs) on medium-chain fatty acyl-acyl carrier protein (acyl-ACP) esters may enable a high-yield microbial production of these molecules. The plant

Indexed as

CupheaFatty AcidsGas Chromatography-Mass SpectrometryPlant ProteinsRecombinant Fusion ProteinsSubstrate SpecificityThiolester HydrolasesFatty Acidsoleoyl-(acyl-carrier-protein) hydrolasePlant ProteinsRecombinant Fusion ProteinsThiolester Hydrolaseschimeric enzymesoctanoic acidprotein engineering

Identifiers

PMID29549102
PMCPMC5930381
OpenAlexW2791407054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.