ArticleEBioMedicine2018
Visual Restoration after Cataract Surgery Promotes Functional and Structural Brain Recovery.
Article in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02644720 (Neural Compensation, Visual Function and Visual Quality in Senile Cataract Patients After Monofocal or Multifocal Intraocular Lens Implantation), which is not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neural Compensation, Visual Function and Visual Quality in Senile Cataract Patients After Monofocal or Multifocal Intraocular Lens Implantation
Who cites it
33 citing papers in PubMed.
- Multiscale Cortical Remodeling Following Abrupt Visual Deafferentation in Rhegmatogenous Retinal Detachment: Imaging Transcriptomics and Neurotransmitter Mapping.CNS neuroscience & therapeutics · 2026Article
- The association of cataract surgery with risk of falls and fractures among Medicare enrollees with cataract.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Comparison of visual quality between the refractive-diffractive hybrid bifocal EDOF and the refractive-diffractive hybrid trifocal IOL.Frontiers in medicine · 2026Article
- Visual impairment predicts greater declines in physical performance over time: the Health, Aging and Body Composition Study.BMC geriatrics · 2025Article
- Unanswered questions regarding the pathogenesis of late onset posterior capsular opacification.Frontiers in ophthalmology · 2025Review
- Aging-associated sensory decline and Alzheimer's disease.Molecular neurodegeneration · 2024Review
- Development and validation of a risk prediction model for motoric cognitive risk syndrome in older adults.Aging clinical and experimental research · 2024Article
- Review
- Anatomical and Functional Impacts of Congenital Bilateral Visual Deprivation on the Visual Pathway-A Comprehensive Review.Journal of clinical medicine · 2024Review
- Sound suppresses earliest visual cortical processing after sight recovery in congenitally blind humans.Communications biology · 2024Article
- Article
- Article
- Postoperative evaluation of visual and cognitive functions following cataract surgery in patients with age-related cataracts: a prospective longitudinal study.Frontiers in neuroscience · 2024Article
- Postoperative myopic shift and visual acuity rehabilitation in patients with bilateral congenital cataracts.Frontiers in medicine · 2024Article
- LensAge index as a deep learning-based biological age for self-monitoring the risks of age-related diseases and mortality.Nature communications · 2023Article
- A Multisite Longitudinal Investigation of Psychological Outcomes Following Cataract Surgery in India.Indian journal of psychological medicine · 2023Article
- Beyond vision:Cataract and health status in old age, a narrative review.Frontiers in medicine · 2023Review
- Intraoperative Complication Rates in Cataract Surgery After Resuming Surgery Following the COVID-19 Shutdown.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Progressive Retinal Degeneration Increases Cortical Response Latency of Light Stimulation but Not of Electric Stimulation.Translational vision science & technology · 2022Article
- Assessing Bias in Cognitive Testing for Older Adults with Sensory Impairment: An Analysis of Differential Item Functioning in the Baltimore Longitudinal Study on Aging (BLSA) and the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS).Journal of the International Neuropsychological Society : JINS · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVisual function and brain function decline concurrently with aging. Notably, cataract patients often present with accelerated age-related decreases in brain function, but the underlying mechanisms are still unclear. Optical structures of the anterior segment of the eyes, such as the lens and cornea, can be readily reconstructed to improve refraction and vision quality. However, the effects of visual restoration on human brain function and structure remain largely unexplored.
methodsA prospective, controlled clinical trial was conducted. Twenty-six patients with bilateral age-related cataracts (ARCs) who underwent phacoemulsification and intraocular lens implantation and 26 healthy controls without ARC, matched for age, sex, and education, were recruited. Visual functions (including visual acuity, visual evoke potential, and contrast sensitivity), the Mini-Mental State Examination and functional magnetic resonance imaging (including the fractional amplitude of low-frequency fluctuations and grey matter volume variation) were assessed for all the participants and reexamined for ARC patients after cataract surgery. This trial was registered with ClinicalTrials.gov (NCT02644720).
findingsCompared with the healthy controls, the ARC patients presented decreased brain functionality as well as structural alterations in visual and cognitive-related brain areas preoperatively. Three months postoperatively, significant functional improvements were observed in the visual and cognitive-related brain areas of the patients. Six months postoperatively, the patients' grey matter volumes in these areas were significantly increased. Notably, both the function and structure in the visual and cognitive-related brain areas of the patients improved significantly and became comparable to those of the healthy controls 6months postoperatively.
interpretationWe demonstrated that ocular reconstruction can functionally and structurally reverse cataract-induced brain changes. The integrity of the eye is essential for maintaining the structure and function of the brain within and beyond the primary visual pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.