ArticleImmunity2018
Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses.
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Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
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Who cites it
53 citing papers in PubMed, 81 citations in OpenAlex.
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- Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy in preclinical mouse models.Science translational medicine · 2026Article
- Phagocytosis: a process that shapes immune responses to engulfed meals.Nature reviews. Immunology · 2026Review
- Single-cell quantification of the microbiota by flow cytometry: MicFLY.bioRxiv : the preprint server for biology · 2025Article
- Germinal Center B cells provide essential IL-1β signals to TFH cells via canonical NLRP3 inflammasome activity post influenza infection.PLoS pathogens · 2025Article
- Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TNature immunology · 2025Article
- IL-1β signaling modulates T follicular helper and regulatory cells in human lymphoid tissues.JCI insight · 2025Article
- STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis.Investigative ophthalmology & visual science · 2025Article
- The danger theory of immunity revisited.Nature reviews. Immunology · 2024Review
- Tailoring TeLife · 2024Article
- Effects of EnterotoxigenicMicroorganisms · 2023Article
- Gut microbiota in colorectal cancer development and therapy.Nature reviews. Clinical oncology · 2023Review
- Intranasal SARS-CoV-2 spike-based immunisation adjuvanted with polyethyleneimine elicits mucosal and systemic humoral responses in mice.Journal of immunological methods · 2022Article
- Context-dependent function of TSLP and IL-1β in skin allergic sensitization and atopic march.Nature communications · 2022Article
- Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome.Nature immunology · 2022Article
- Article
- Strong influenza-induced TProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Translating known drivers of COVID-19 disease severity to design better SARS-CoV-2 vaccines.Current opinion in virology · 2022Review
- Gut Microbiome and Bile Acid Metabolism Induced the Activation of CXCR5+ CD4+ T Follicular Helper Cells to Participate in Neuromyelitis Optica Spectrum Disorder Recurrence.Frontiers in immunology · 2022Article
- Systematic characterization of human gut microbiome-secreted molecules by integrated multi-omics.ISME communications · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Gaetan BarbetThe Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Leif E SanderDepartment of Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Matthew GeswellImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Irina LeonardiThe Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Andrea CeruttiImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institut Hospital del Mar 'Investigacions Mèdiques, Barcelona Biomedical Research Park, Barcelona, Spain; Catalan Institute for Research and Advanced Studies (ICREA), Barcelona, 08003, Spain.
Iliyan IlievThe Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY, USA.
J Magarian BlanderThe Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Cornell University, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: jmblander@med.cornell.edu.
Cornell University · USHumboldt-Universität zu Berlin · DEIcahn School of Medicine at Mount Sinai · USInstitució Catalana de Recerca i Estudis Avançats · ES
Funding
Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8MTHE ROLE OF ICSBP IN MUCOSAL IMMUNE RESPONSEP01DK072201 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HARPAZ, NOAM · 2006 to 2015
$14.6MRegulation of antibody production by innate signalsR01AI057653 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CERUTTI, ANDREA · 2005 to 2016
$4.3MCommensal fungal communities in the regulation of immunity and intestinal inflammation.R01DK113136 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIYAN Dimitrov ILIEV · 2017 to 2026
$4.2MThe Regulatory Control Mechanisms of Cross-presentation by Toll-like ReceptorsR01AI073899 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BLANDER, JULIE MAGARIAN · 2008 to 2012
$2.1MNovel vita-vaccine formula combines safety of dead and efficacy of live vaccinesR01AI127658 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLANDER, JULIE MAGARIAN · 2016 to 2020
$2.1MNon-Canonical Cross-presentation in Dendritic Cells Upon TAP BlockadeR01AI123284 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLANDER, JULIE MAGARIAN · 2016 to 2020
$2.1MRegulation and Function of Immunoglobulin D in Mucosal Immune DefenseU01AI095613 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CERUTTI, ANDREA · 2011 to 2015
$2.1MControl of protective immunity by innate pathways sensing bacterial viabilityR01AI095245 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BLANDER, JULIE MAGARIAN · 2012 to 2015
$1.7MRole of apoptosis in the intestinal epithelium during homeostasis and diseaseR01DK111862 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLANDER, JULIE MAGARIAN · 2017 to 2020
$1.5MInnate Immune Sensing of Microbial ViabilityR21AI080959 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BLANDER, JULIE MAGARIAN · 2009 to 2010
$466kThe Regulatory Control Mechanisms of Cross-presentation by Toll-like ReceptorsR56AI073899 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BLANDER, JULIE MAGARIAN · 2007 to 2007
$424kNIAID NIH HHS P01 AI061093NIAID NIH HHS R01 AI057653NIAID NIH HHS R01 AI073899NIAID NIH HHS R01 AI095245NIAID NIH HHS R01 AI123284NIAID NIH HHS R01 AI127658NIAID NIH HHS R21 AI080959NIAID NIH HHS R56 AI073899NIAID NIH HHS U01 AI095613NIDDK NIH HHS P01 DK072201NIDDK NIH HHS R01 DK111862NIDDK NIH HHS R01 DK113136
Abstract
Live vaccines historically afford superior protection, yet the cellular and molecular mechanisms mediating protective immunity remain unclear. Here we found that vaccination of mice with live, but not dead, Gram-negative bacteria heightened follicular T helper cell (Tfh) differentiation, germinal center formation, and protective antibody production through the signaling adaptor TRIF. Complementing the dead vaccine with an innate signature of bacterial viability, bacterial RNA, recapitulated these responses. The interferon (IFN) and inflammasome pathways downstream of TRIF orchestrated Tfh responses extrinsically to B cells and classical dendritic cells. Instead, CX3CR1
Indexed as
Adaptor Proteins, Vesicular TransportAnimalsAntibodies, NeutralizingAntibody FormationAntigen-Presenting CellsBacterial VaccinesBiomarkersB-LymphocytesCell DifferentiationCytokinesGerminal CenterHost-Pathogen InteractionsImmunity, CellularImmunity, InnateInflammasomesLymphocyte ActivationAdaptor Proteins, Vesicular TransportAntibodies, NeutralizingBacterial VaccinesBiomarkersCytokinesIL1R1 protein, mouseInflammasomesReceptor, Interferon alpha-betaReceptors, Interleukin-1 Type IRNA, BacterialTicam1 protein, mouseBacterial RNACX3CR1Follicular T helper cellinflammasomemicrobial viabilitymonocytestype-I interferonvaccine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.