Evidence map›Paper›PMID 29548604›Full record

ArticleVaccine2018

Effect of influenza vaccine on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in older adults.

Maryam Keshtkar-Jahromi, Min Ouyang, Marzieh Keshtkarjahromi, Samah Almed, Huifen Li, Jeremy D Walston, Rebeca Rios, Sean X Leng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Maryam Keshtkar-JahromiDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: maryam.keshtkar@jhmi.edu.
Min OuyangDepartment of Geriatrics, the Second Hospital of Central South University Medical School, Changsha, Hunan Province, China. Electronic address: Mindy.gao@163.com.
Marzieh KeshtkarjahromiDivision of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: mkeshtkar-jahromi@som.umaryland.edu.
Samah AlmedDivision of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: sahmed8@neomed.edu.
Huifen LiDivision of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: hli55@jhmi.edu.
Jeremy D WalstonDivision of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: JWALSTON@jhmi.edu.
Rebeca RiosBiostatistics, Epidemiology, and Database (BEAD) Core; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: rrios2@jhmi.edu.
Sean X LengDivision of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: sleng1@jhmi.edu.
Johns Hopkins University · USCentral South University · CN

Funding

Influenza vaccine failure in adults over age 75: role of chronic CMV infectionR01AI108907 · NIAID · JOHNS HOPKINS UNIVERSITY · PI LENG, SEAN XIAO · 2014 to 2018
$2.8M
NIAID NIH HHS R01 AI108907
6 · The paper itself

Abstract

Influenza immunization is recommended for older adults annually, and has been reported to have cardiovascular protective effects. TNF-related weak inducer of apoptosis (TWEAK), an inflammatory mediator implicated in the development of cardiovascular diseases, could be a mechanism for such effect. The objective of this study was to evaluate the effect of influenza vaccine on TWEAK levels. Older persons over 70 years of age were recruited during 2007-2008 influenza season and immunized with the standard dose trivalent inactivated influenza vaccine. Frailty was evaluated using a validated set of criteria. Sera were collected immediately before and during the 4th week after vaccination. Pre- and post-vaccination levels of TWEAK, soluble CD163 (sCD163) and strain-specific influenza antibody titers were measured in 69 participants. Multiple regression analyses were employed to examine the effect of influenza vaccine on TWEAK and sCD163, adjusting for age, sex, and hypertension. Post-vaccination TWEAK [mean ± standard deviation (SD) = 591.7 ± 290.1 pg/ml] was significantly lower than pre-vaccination level (690.6 ± 330.0 pg/ml) (p = .003). No significant difference was observed between pre and post-vaccination sCD163 levels (p = .71). Post-vaccination TWEAK levels were significantly higher in men (p = .01) and in participants with college or higher level of education (p = .044). There was no significant difference in post-vaccination TWEAK according to other demographics or pre-existing medical conditions. A 2-fold or greater antibody titer against H1N1 vaccine strain was associated with a more pronounced reduction in TWEAK at the p < .10 level (p = .091). A time by frailty interaction term (p = .091) indicated that the vaccination-induced reduction of TWEAK was greatest among frail individuals. These results of this observational study indicate that the impact of Influenza vaccine on TWEAK, including the role of specific antibody responses of specific vaccine strains and frailty status, warrants further investigation. Such investigation may elucidate whether this effect plays a role in mediating cardiovascular protection of influenza vaccination.

Indexed as

AgedAged, 80 and overAge FactorsAntibodies, ViralAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkersCD163 AntigenCytokine TWEAKFemaleHumansInfluenza, HumanInfluenza VaccinesMaleReceptors, Cell SurfaceVaccinationAntibodies, ViralAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkersCD163 AntigenCytokine TWEAKInfluenza VaccinesReceptors, Cell SurfaceTNFSF12 protein, humanCardiovascular diseaseFrailtyInfluenza vaccinesCD163TWEAK

Identifiers

PMID29548604
PMCPMC5889121
OpenAlexW2791147216

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.