ArticleGenome biology2018
Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.
Erratum issuedOpen access · goldAbstract readVideo-Audio Media
In one paragraph
Article in Genome biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma.Frontiers of medicine · 2021Pooled it
- Molecular landscape and clinical translation of DNA damage response alterations in solid tumors: A pan-cancer perspective on precision oncology.Neoplasia (New York, N.Y.) · 2026Review
- Ubiquitin-dependent degradation of p27Kip1 and p21Waf1/Cip1 by AMBRA1 ensures G1 and S phase progression and limits replication stress.Nucleic acids research · 2026Article
- Deciphering molecular pathways in urological cancers: A gateway to precision therapeutics.Journal of advanced research · 2026Review
- Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Germline variant affecting p53β isoforms predisposes to familial cancer.Nature communications · 2024Article
- The paradox of senescent-marker positive cancer cells: challenges and opportunities.npj aging · 2024Review
- Prophylactic senolytic treatment in aged mice reduces seizure severity and improves survival from Status Epilepticus.Aging cell · 2024Article
- Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner.Nature aging · 2023Article
- Single Cell Determination of 7,8-dihydro-8-oxo-2'-deoxyguanosine by Fluorescence Techniques: Antibody vs. Avidin Labeling.Molecules (Basel, Switzerland) · 2023Article
- Effects on Goat Meat Extracts on α-Glucosidase Inhibitory Activity, Expression of Bcl-2-Associated X (BAX), p53, and p21 in Cell Line and Expression of Atrogin-1, Muscle Atrophy F-Box (MAFbx), Muscle RING-Finger Protein-1 (MuRF-1), and Myosin Heavy Chain-7 (MYH-7) in C2C12 Myoblsts.Food science of animal resources · 2023Article
- Increased Gene Targeting in Hyper-Recombinogenic LymphoBlastoid Cell Lines Leaves Unchanged DSB Processing by Homologous Recombination.International journal of molecular sciences · 2022Article
- Revisiting the Function of p21International journal of molecular sciences · 2022Review
- Author Correction: Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.Genome biology · 2022Article
- Nitroglycerin-induced downregulation of AKT- and ERK1/2-mediated radiation-sensitive 52 expression to enhance pemetrexed-induced cytotoxicity in human lung cancer cells.Toxicology research · 2022Article
- Role of Senescence in Tumorigenesis and Anticancer Therapy.Journal of oncology · 2022Review
- Article
- The Role ofInternational journal of molecular sciences · 2021Article
- Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA Double-Strand Break Repair Mechanisms.Cells · 2021Review
- Anti-Leukemic Properties of Aplysinopsin Derivative EE-84 Alone and Combined to BH3 Mimetic A-1210477.Marine drugs · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
21 authors at 11 institutions in 7 countries.
Panagiotis GalanosMolecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, 75 Mikras Asias Str, GR-11527, Athens, Greece.
George PappasMolecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, 75 Mikras Asias Str, GR-11527, Athens, Greece.
Alexander PolyzosBiomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou Str, GR-11527, Athens, Greece.
Athanassios KotsinasMolecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, 75 Mikras Asias Str, GR-11527, Athens, Greece.
Ioanna SvolakiMolecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, 75 Mikras Asias Str, GR-11527, Athens, Greece.
Nickolaos N GiakoumakisLaboratory of Biology, School of Medicine, University of Patras, 26505, Patras, Rio, Greece.
Christina GlytsouDepartment of Biology, University of Padova, 35121, Padova, Italy.
Ioannis S PaterasMolecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, 75 Mikras Asias Str, GR-11527, Athens, Greece.
Umakanta SwainDepartment of Biomolecular Sciences, Weizmann Institute of Science, 76100, Rehovot, Israel.
Vassilis L SouliotisInstitute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave, GR-11635, Athens, Greece.
Alexandros G GeorgakilasPhysics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), 15780, Zografou, Athens, Greece.
Nicholas GeacintovDepartment of Chemistry, New York University, New York, 10012, USA.
Luca ScorranoDepartment of Biology, University of Padova, 35121, Padova, Italy.
Claudia LukasNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jiri LukasNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Zvi LivnehDepartment of Biomolecular Sciences, Weizmann Institute of Science, 76100, Rehovot, Israel.
Zoi LygerouLaboratory of Biology, School of Medicine, University of Patras, 26505, Patras, Rio, Greece.
Dipanjan ChowdhuryDepartment of Radiation Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
Claus Storgaard SørensenBiotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaloes Vej 5, DK-2200, Copenhagen, Denmark.
Jiri BartekDanish Cancer Society Research Centre, Strandboulevarden 49, DK-2100, Copenhagen, Denmark. jb@cancer.dk.
Vassilis G GorgoulisMolecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, 75 Mikras Asias Str, GR-11527, Athens, Greece. vgorg@med.uoa.gr.
National and Kapodistrian University of Athens · GRUniversity of Copenhagen · DKUniversity of Padua · ITUniversity of Patras · GRWeizmann Institute of Science · ILAcademy of Athens · GRHarvard University · USNational Hellenic Research Foundation · GRNational Technical University of Athens · GRNew York University · USScience for Life Laboratory · SE
Funding
Danish National Research Foundation CARDHorizon 2020 722729
Abstract
backgroundGenomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic strategies. In a previous study, we reported an unexpected oncogenic property of p21
resultsWe now demonstrate that p21
conclusionsOur results signify the importance of mutational signatures as guides to disclose the repair history leading to genomic instability. We unveil how chronic p21
Indexed as
DNA RepairGenomic InstabilityMutationCell LineCyclin-Dependent Kinase Inhibitor p21DNAHumansRad52 DNA Repair and Recombination ProteinTumor Suppressor Protein p53CDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21DNARad52 DNA Repair and Recombination ProteinTumor Suppressor Protein p53Break-induced replication (BIR)Genomic instabilityp21WAF1/Cip1Rad52Single nucleotide substitution (SNS)Single strand annealing (SSA)Translesion DNA synthesis (TLS)
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.