ArticleBMC complementary and alternative medicine2018
Taraxacum officinale and Urtica dioica extracts inhibit dengue virus serotype 2 replication in vitro.
Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives.Biomolecules · 2019Pooled it
- Efficacy of Persian medicine herbal formulations (capsules and decoction) compared to standard care in patients with COVID-19, a multicenter open-labeled, randomized, controlled clinical trial.Phytotherapy research : PTR · 2021Trial
- Achievements and Approaches in the Search for Small-Molecule Dengue NS2B/NS3 Inhibitors.Current medicinal chemistry · 2026Review
- Article
- Exploring the Medicinal Potential ofMetabolites · 2025Article
- Bioactive Compounds from Vegetal Organs ofInternational journal of molecular sciences · 2025Review
- Anti-DENV-2 Activity of Ethanolic Extracts fromPlants (Basel, Switzerland) · 2024Article
- In Vitro Bioactivities of Food Grade Extracts from Yarrow (Achillea millefolium L.) and Stinging Nettle (Urtica dioica L.) Leaves.Plant foods for human nutrition (Dordrecht, Netherlands) · 2023Article
- Papaya Leaf Extracts as Potential Dengue Treatment: An In-Silico Study.International journal of molecular sciences · 2022Article
- Antiviral activity of dandelion aqueous extract against pseudorabies virus bothFrontiers in veterinary science · 2022Article
- Article
- The basic helix-loop-helix transcription factor TabHLH1 increases chlorogenic acid and luteolin biosynthesis in Taraxacum antungense Kitag.Horticulture research · 2021Article
- In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19.Biomolecules · 2021Article
- Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses.Plants (Basel, Switzerland) · 2020Review
- Anti-inflammatory and antinociceptive effects of an ethanol extract from Senna septemtrionalis.Inflammopharmacology · 2020Article
- Inhibitory Effects ofAntioxidants (Basel, Switzerland) · 2020Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundUrtica dioica, Taraxacum officinale, Calea integrifolia and Caesalpinia pulcherrima are widely used all over the world for treatment of different illnesses. In Mexico, these plants are traditionally used to alleviate or counteract rheumatism and inflammatory muscle diseases. In the present study we evaluated the activity of aqueous and methanolic extracts of these four plants, on the replication of dengue virus serotype 2 (DENV2).
methodsExtraction process was carried out in a Soxtherm® system at 60, 85 and 120 °C; a chemical fractionation in silica gel chromatography was performed and compounds present in the active fractions were identified by HPLC-DAD-ESI/MSn. The cytotoxic concentration and the inhibitory effect of extracts or fractions on the DENV2 replication were analyzed in the BHK-21 cell line (plaque forming assay). The half maximal inhibitory concentration (IC
resultsThe methanolic extracts at 60 °C of T. officinale and U. dioica showed the higher inhibitory effects on DENV2 replication. After the chemical fractionation, the higher activity fraction was found for U. dioica and T. officinale, presenting IC
conclusionsTwo fractions from U. dioica and T. officinale methanolic extracts with anti-dengue activity were found. The compounds present in both fractions were identified, several recognized molecules have demonstrated activity against other viral species. Subsequent biological analysis of the molecules, alone or in combination, contained in the extracts will be carried out to develop therapeutics against DENV2.
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