Evidence map›Paper›PMID 29547931›Full record

ArticleInternational journal of epidemiology2018

Prospective evaluation of body size and breast cancer risk among BRCA1 and BRCA2 mutation carriers.

Shana J Kim, Tomasz Huzarski, Jacek Gronwald, Christian F Singer, Pål Møller, Henry T Lynch, Susan Armel, Beth Y Karlan, William D Foulkes, Susan L Neuhausen and 11 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Complex Interplay Between Obesity and BRCA1/2-Associated Breast Cancer: An Overview.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Cancers · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 18 institutions in 6 countries.

Shana J KimWomen's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.
Tomasz HuzarskiDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Jacek GronwaldDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Christian F SingerDepartment of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Pål MøllerInherited Cancer Research Group, Department for Medical Genetics, Oslo University Hospital, Oslo, Norway.
Henry T LynchHereditary Cancer Center, Creighton University School of Medicine, Omaha, NE, USA.
Susan ArmelDepartment of Gynecologic Oncology, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
Beth Y KarlanWomen's Cancer Program, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
William D FoulkesProgram in Cancer Genetics, Department of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Leigha SenterDivision of Human Genetics, Ohio State University Medical Center, Comprehensive Cancer Center, Columbus, OH, USA.
Andrea EisenOdette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Charis EngGenomic Medicine Institute, Center for Personalized Genetic Healthcare, Cleveland Clinic, Cleveland, OH, USA.
Seema PanchalMount Sinai Hospital, Toronto, Ontario, Canada.
Tuya PalVanderbilt-Ingram Cancer Center/Vanderbilt University Medical Center, Nashville, TN, USA.
Olufunmilayo OlopadeDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Dana ZakalikCancer Genetics Program, Beaumont Hospital, Royal Oak, MI, USA.
Jan LubinskiDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Steven A NarodWomen's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.
Joanne KotsopoulosWomen's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.
Hereditary Breast Cancer Clinical Study Group
Women's College Hospital · CAInternational Hereditary Cancer Center · PLCancer Genetics (United States) · USCedars-Sinai Medical Center · USCity of Hope · USCleveland Clinic · USCreighton University · USMcGill University · CAMedical University of Vienna · ATMount Sinai Hospital · CAOslo University Hospital · NOPomeranian Medical University · PLPrincess Margaret Cancer Centre · CAPublic Health Ontario · CASunnybrook Health Science Centre · CAThe Ohio State University Wexner Medical Center · USUniversity of Chicago · USVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough evidence suggests that larger body size in early life confers lifelong protection from developing breast cancer, few studies have investigated the relationship between body size and breast cancer risk among BRCA mutation carriers. Therefore, we conducted a prospective evaluation of body size and the risk of breast cancer among BRCA mutation carriers.

methodsCurrent height and body mass index (BMI) at age 18 were determined from baseline questionnaires. Current BMI and weight change since age 18 were calculated from updated biennial follow-up questionnaires. Cox proportional hazards models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI).

resultsAmong 3734 BRCA mutation carriers, there were 338 incident breast cancers over a mean follow-up of 5.5 years. There was no association between height, current BMI or weight change and breast cancer risk. Women with BMI at age 18 ≥22.1 kg/m2 had a decreased risk of developing post-menopausal breast cancer compared with women with a BMI at age 18 between 18.8 and 20.3 kg/m2 (HR 0.49; 95% CI 0.30-0.82; P = 0.006). BMI at age 18 was not associated with risk of pre-menopausal breast cancer.

conclusionsThere was no observed association between height, current BMI and weight change and risk of breast cancer. The inverse relationship between greater BMI at age 18 and post-menopausal breast cancer further supports a role of early rather than current or adulthood exposures for BRCA-associated breast cancer development. Future studies with longer follow-up and additional measures of adiposity are necessary to confirm these findings.

Indexed as

BMIbody sizeBRCAbreast cancerhereditary cancer

Identifiers

PMID29547931
PMCPMC6005062
OpenAlexW2790346816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.