Evidence map›Paper›PMID 29547587›Full record

ReviewGenes2018

Dietary Alteration of the Gut Microbiome and Its Impact on Weight and Fat Mass: A Systematic Review and Meta-Analysis.

George Kunnackal John, Lin Wang, Julie Nanavati, Claire Twose, Rajdeep Singh, Gerard Mullin

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05358301 (Novel Strategies for Obesity Prevention and Management With the Probiotic Lactiplantibacillus Plantarum IMC 510), which is not on this map. Cited by 66 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05358301 nacompletednot on this mapstarted 2022, after this paper: background citation

Novel Strategies for Obesity Prevention and Management With the Probiotic Lactiplantibacillus Plantarum IMC 510 (PRO-Weight-Control Study)

TypeinterventionalSponsorAzienda Ospedaliero-Universitaria CareggiRan2022 to 2022Enrolled40ConditionsObesityArmsProbiotic, Placebo
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

George Kunnackal JohnJohns Hopkins University School of Medicine, Baltimore, MD 21205, USA. gjohn3@jhmi.edu.ORCID 0000-0002-0595-5434
Lin WangJohns Hopkins School of Public Health, Baltimore, MD 21205, USA. linwang@jhu.edu.ORCID 0000-0003-1338-2100
Julie NanavatiJohns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jnanava1@jhmi.edu.
Claire TwoseJohns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ctwose@jhmi.edu.
Rajdeep SinghSinai Hospital, Baltimore, MD 21215, USA. rajdeepw17@gmail.com.
Gerard MullinJohns Hopkins University School of Medicine, Baltimore, MD 21205, USA. gmullin1@jhmi.edu.ORCID 0000-0001-5317-6788

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary alteration of the gut microbiome is an important target in the treatment of obesity. Animal and human studies have shown bidirectional weight modulation based on the probiotic formulation used. In this study, we systematically reviewed the literature and performed a meta-analysis to assess the impact of prebiotics, probiotics and synbiotics on body weight, body mass index (BMI) and fat mass in adult human subjects. We searched Medline (PubMed), Embase, the Cochrane Library and the Web of Science to identify 4721 articles, of which 41 were subjected to full-text screening, yielding 21 included studies with 33 study arms. Probiotic use was associated with significant decreases in BMI, weight and fat mass. Studies of subjects consuming prebiotics demonstrated a significant reduction in body weight, whereas synbiotics did not show an effect. Overall, when the utilization of gut microbiome-modulating dietary agents (prebiotic/probiotic/synbiotic) was compared to placebo, there were significant decreases in BMI, weight and fat mass. In summary, dietary agents for the modulation of the gut microbiome are essential tools in the treatment of obesity and can lead to significant decreases in BMI, weight and fat mass. Further studies are needed to identify the ideal dose and duration of supplementation and to assess the durability of this effect.

Indexed as

gut microbiomeobesity treatmentprobioticsweight loss

Identifiers

PMID29547587
PMCPMC5867888

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.