Evidence map›Paper›PMID 29547545›Full record

ArticleInternational journal of molecular sciences2018

Prediction of Tacrolimus Exposure by CYP3A5 Genotype and Exposure of Co-Administered Everolimus in Japanese Renal Transplant Recipients.

Hideaki Kagaya, Takenori Niioka, Mitsuru Saito, Takamitsu Inoue, Kazuyuki Numakura, Ryohei Yamamoto, Yumiko Akamine, Tomonori Habuchi, Shigeru Satoh, Masatomo Miura

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Effects ofInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hideaki KagayaDepartment of Pharmacy, Akita University Hospital, 1-1-1 Hondo, Akita 010-8543, Japan. hideaki-kagaya@hos.akita-u.ac.jp.
Takenori NiiokaDepartment of Pharmacy, Akita University Hospital, 1-1-1 Hondo, Akita 010-8543, Japan. t-niioka@hirosaki-u.ac.jp.
Mitsuru SaitoDepartment of Urology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. mitsaito@med.akita-u.ac.jp.
Takamitsu InoueDepartment of Urology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. takamitu@doc.med.akita-u.ac.jp.ORCID 0000-0002-1362-4344
Kazuyuki NumakuraDepartment of Urology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. numakura@doc.med.akita-u.ac.jp.
Ryohei YamamotoDepartment of Urology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. yama815@med.akita-u.ac.jp.
Yumiko AkamineDepartment of Pharmacy, Akita University Hospital, 1-1-1 Hondo, Akita 010-8543, Japan. yumiko-ai@hos.akita-u.ac.jp.
Tomonori HabuchiDepartment of Urology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. thabuchi@doc.med.akita-u.ac.jp.
Shigeru SatohCenter for Kidney Disease and Transplantation, Akita University Hospital, 1-1-1 Hondo, Akita 010-8543, Japan. shigerus@doc.med.akita-u.ac.jp.
Masatomo MiuraDepartment of Pharmacy, Akita University Hospital, 1-1-1 Hondo, Akita 010-8543, Japan. m-miura@hos.akita-u.ac.jp.
Akita University · JPAkita University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While tacrolimus and everolimus have common metabolic pathways through CYP3A4/5, tacrolimus is metabolized solely by CYP3A4 in recipients with the

Indexed as

Kidney TransplantationAllelesArea Under CurveCalcineurin InhibitorsCytochrome P-450 CYP3ADrug Therapy, CombinationEverolimusFemaleGenotypeHumansImmunosuppressive AgentsJapanMaleMiddle AgedPolymorphism, Single NucleotideRetrospective StudiesCalcineurin InhibitorsCYP3A5 protein, humanCytochrome P-450 CYP3AEverolimusImmunosuppressive AgentsTacrolimusCYP3A5 polymorphismeverolimusrenal transplantationtacrolimus

Identifiers

PMID29547545
PMCPMC5877743
OpenAlexW2791465706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.