The Replacement of five Consecutive Amino Acids in the Cyt1A Protein of Bacillus thuringiensis Enhances its Cytotoxic Activity against Lung Epithelial Cancer Cells.

Kavita Nair, Ahmad Iskandarani, Roda Al-Thani, Ramzi Mohammad, Samir Jaoua

Open access · goldAbstract read

In one paragraph

Article in Toxins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 44% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

Parasporin A13-2 ofToxins · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Kavita NairBiological & Environmental Sciences Department, College of Arts and Sciences, Qatar University, P.O. Box 2713 Doha, Qatar. kavita.nair@qu.edu.qa.

Ahmad IskandaraniInterim Translational Research Institute, Hamad Medical Corporation, P.O. Box 3050 Doha, Qatar. aiskandarani@hamad.qa.

Roda Al-ThaniBiological & Environmental Sciences Department, College of Arts and Sciences, Qatar University, P.O. Box 2713 Doha, Qatar. ralthani@qu.edu.qa.

Ramzi MohammadKarmanos Cancer Institute, Wayne State University, 732 HWCRC, 4100 John R., Detroit, MI 48201, USA. mohammar@karmanos.org.

Samir JaouaBiological & Environmental Sciences Department, College of Arts and Sciences, Qatar University, P.O. Box 2713 Doha, Qatar. samirjaoua@qu.edu.qa.ORCID 0000-0002-8819-131X

Qatar University · QAHamad Medical Corporation · QAWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyt1A protein is a cytolytic protein encoded by the

Indexed as

Amino Acid SubstitutionBacillus thuringiensis ToxinsBacterial ProteinsCell Line, TumorCell SurvivalEndotoxinsEpithelial CellsHemolysin ProteinsHumansLungBacillus thuringiensis ToxinsBacterial ProteinsEndotoxinsHemolysin Proteinsinsecticidal crystal protein, Bacillus ThuringiensisBacillus thuringiensis subsp. israelensiscytotoxicitylung epithelial cancer cell lineNovel Cyt1Aprotein modelling

Identifiers

PMID29547530

DOI10.3390/toxins10030125

PMCPMC5869413

OpenAlexW2791224012

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.