Evidence map›Paper›PMID 29547267›Full record

ArticleJournal of agricultural and food chemistry2018

Cytotoxic Effects of 24-Methylenecyloartanyl Ferulate on A549 Nonsmall Cell Lung Cancer Cells through MYBBP1A Up-Regulation and AKT and Aurora B Kinase Inhibition.

Sofia Doello, Zhibin Liang, Il Kyu Cho, Jung Bong Kim, Qing X Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of agricultural and food chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 3 countries.

Sofia DoelloDepartment of Molecular Biosciences and Bioengineering , University of Hawaii at Manoa , Honolulu , Hawaii 96822 , United States.ORCID http://orcid.org/0000-0002-4025-3016
Zhibin LiangDepartment of Molecular Biosciences and Bioengineering , University of Hawaii at Manoa , Honolulu , Hawaii 96822 , United States.ORCID http://orcid.org/0000-0002-8855-1696
Il Kyu ChoDepartment of Molecular Biosciences and Bioengineering , University of Hawaii at Manoa , Honolulu , Hawaii 96822 , United States.
Jung Bong KimDepartment of Molecular Biosciences and Bioengineering , University of Hawaii at Manoa , Honolulu , Hawaii 96822 , United States.
Qing X LiDepartment of Molecular Biosciences and Bioengineering , University of Hawaii at Manoa , Honolulu , Hawaii 96822 , United States.ORCID http://orcid.org/0000-0003-4589-2869
University of Hawaiʻi at Mānoa · US

Funding

RESEARCH DESIGN, BIOSTATISTICS AND RESEARCH ETHICS COREG12MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI BERRY, MARLA J · 2012 to 2016
$13.0M
NIMHD NIH HHS G12 MD007601
6 · The paper itself

Abstract

Lung cancer is the second most prevalent cancer. Nonsmall cell lung cancer (NSCLC) is the most common type of lung cancer. The low efficacy in current chemotherapies impels us to find new alternatives to prevent or treat NSCLC. Rice bran oil is cytotoxic to A549 cells, a NSCLC cell line. Here, we identified 24-methylenecyloartanyl ferulate (24-mCAF) as the main component responsible for the cytotoxicity in A549 cells. An iTRAQ-based quantitative proteomics analysis revealed that 24-mCAF inhibits cell proliferation and activates cell death and apoptosis. 24-mCAF induces up-regulation of Myb binding protein 1A (MYBBP1A), a tumor suppressor that halts cancer progression. 24-mCAF inhibits the activity of AKT and Aurora B kinase, two Ser/Thr kinases involved in MYBBP1A regulation and that represent important targets in NSCLC. This study provides the first insight of the effect of 24-mCAF, the main component of rice bran oil, on A459 cells at the cellular and molecular levels.

Indexed as

A549 CellsAntineoplastic AgentsAurora Kinase BCarcinoma, Non-Small-Cell LungCell ProliferationDNA-Binding ProteinsHumansLung NeoplasmsNuclear ProteinsNucleocytoplasmic Transport ProteinsOncogene Protein v-aktPhenylpropionatesProtein Kinase InhibitorsRNA-Binding ProteinsSignal TransductionTranscription FactorsAntineoplastic AgentsAURKB protein, humanAurora Kinase BDNA-Binding Proteinsgamma-oryzanolMYBBP1A protein, humanNuclear ProteinsNucleocytoplasmic Transport ProteinsOncogene Protein v-aktPhenylpropionatesProtein Kinase InhibitorsRNA-Binding ProteinsTranscription Factors24-methylenecyloartanyl ferulateiTRAQnonsmall cell lung canceroryzanolquantitative proteomicsrice bran

Identifiers

PMID29547267
PMCPMC7412982
OpenAlexW2790261839

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.