Evidence map›Paper›PMID 29546595›Full record

ArticleJournal of the American Society for Mass Spectrometry2018

Gas Phase Ion Chemistry to Determine Isoaspartate in a Peptide Backbone.

S T Ayrton, X Chen, R M Bain, C J Pulliam, M Achmatowicz, T G Flick, D Ren, R G Cooks

Abstract read
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In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

S T AyrtonDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA.
X ChenDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA.
R M BainDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA.
C J PulliamDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA.
M AchmatowiczDepartment of Analytical Research & Development, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, CA, 91320, USA.
T G FlickDepartment of Analytical Research & Development, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, CA, 91320, USA.
D RenDepartment of Analytical Research & Development, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, CA, 91320, USA.
R G CooksDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, USA. cooks@purdue.edu.
Purdue University West Lafayette · USAmgen (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proof of concept evidence is presented for a new method for the determination of isoaspartate, an important post-translational modification. Chemical derivatization is performed using common reagents for the modification of carboxylic acids and shown to yield suitable diagnostic information with regard to isomerization at the aspartate residue. The diagnostic gas phase chemistry is probed by collision-induced dissociation mass spectrometry, on the timescale of the MS experiment and semi-quantitative calibration of the percentage of isoaspartate in a peptide sample is demonstrated. Graphical Abstract ᅟ.

Indexed as

CalibrationIsoaspartic AcidPeptidesProtein Processing, Post-TranslationalSpectrometry, Mass, Electrospray IonizationIsoaspartic AcidPeptidesIsobaric peptideMass spectrometryNanoelectrospray ionizationPost-translational modification

Identifiers

PMID29546595
OpenAlexW2791880148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.