Evidence map›Paper›PMID 29546593›Full record

ArticleMolecular neurobiology2018

MARCKS Is Necessary for Netrin-DCC Signaling and Corpus Callosum Formation.

J J Brudvig, J T Cain, G G Schmidt-Grimminger, D J Stumpo, K J Roux, P J Blackshear, J M Weimer

Open access · hybridAbstract read
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Proximity-dependent labeling methods for proteomic profiling in living cells: An update.Wiley interdisciplinary reviews. Developmental biology · 2021
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. BioID: A Method to Generate a History of Protein Associations.Methods in molecular biology (Clifton, N.J.) · 2019
    Article
  11. Article
  12. Review
  13. Revisiting Netrin-1: One Who Guides (Axons).Frontiers in cellular neuroscience · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

J J BrudvigPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, 57104, USA.
J T CainPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, 57104, USA.
G G Schmidt-GrimmingerPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, 57104, USA.
D J StumpoSignal Transduction Laboratory, National Institute of Environmental Health Science, Research Triangle Park, NC, 27709, USA.
K J RouxEnabling Technologies Group, Sanford Research, Sioux Falls, SD, 57104, USA.
P J BlackshearSignal Transduction Laboratory, National Institute of Environmental Health Science, Research Triangle Park, NC, 27709, USA.
J M WeimerPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, 57104, USA. Jill.Weimer@sanfordhealth.org.
Sanford Research · USNational Institute of Environmental Health Sciences · USUniversity of South Dakota · US

Funding

TTP and related proteins in the regulation of gene expressionZIAES090080 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BLACKSHEAR, PERRY J · 2009 to 2025
$52.6M
Yeast 2 HybridP20GM103620 · NIGMS · SANFORD RESEARCH/USD · PI ROUX, KYLE J · 2013 to 2023
$24.2M
Novel mechanisms for distal transport in developing and mature neuronsR01NS082283 · NINDS · SANFORD RESEARCH/USD · PI WEIMER, JILL M · 2014 to 2018
$1.9M
Developing methods for proximity-dependent protein labelingR01GM102203 · NIGMS · SANFORD RESEARCH/USD · PI ROUX, KYLE J · 2013 to 2017
$1.5M
National Institute of Neurological Disorders and Stroke (US) R01NS082283NIGMS NIH HHS P20 GM103620NIGMS NIH HHS P20GM103620NIGMS NIH HHS R01 GM102203NINDS NIH HHS R01 NS082283
6 · The paper itself

Abstract

Axons of the corpus callosum (CC), the white matter tract that connects the left and right hemispheres of the brain, receive instruction from a number of chemoattractant and chemorepulsant cues during their initial navigation towards and across the midline. While it has long been known that the CC is malformed in the absence of Myristoylated alanine-rich C-kinase substrate (MARCKS), evidence for a direct role of MARCKS in axon navigation has been lacking. Here, we show that MARCKS is necessary for Netrin-1 (NTN1) signaling through the DCC receptor, which is critical for axon guidance decisions. Marcks null (Marcks

Indexed as

Signal TransductionAnimalsAxonsCell MembraneCorpus CallosumDCC ReceptorEmbryo, MammalianFocal Adhesion Kinase 1Mice, Inbred C57BLModels, BiologicalMyristoylated Alanine-Rich C Kinase SubstrateNetrinsPhosphorylationProtein Bindingsrc-Family KinasesDcc protein, mouseDCC ReceptorFocal Adhesion Kinase 1Marcks protein, mouseMyristoylated Alanine-Rich C Kinase SubstrateNetrinsPtk2 protein, mousesrc-Family KinasesAxon guidanceDccMarcksPtk2Src

Identifiers

PMID29546593
PMCPMC6139093
OpenAlexW2791835402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.