ArticleJournal of abnormal child psychology2019
Early Origins of Autism Comorbidity: Neuropsychiatric Traits Correlated in Childhood Are Independent in Infancy.
Article in Journal of abnormal child psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Heritability of Psychological Traits and Developmental Milestones in Infancy: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- Dysregulated Irritability as a Window on Young Children's Psychiatric Risk: Transdiagnostic Effects via the Family Check-Up.Development and psychopathology · 2019Trial
- Mate selection and current trends in the prevalence of autism.Molecular autism · 2024Article
- Independent Contributions of Callous-Unemotional Behaviors and Quantitative Autistic Traits to Aggression in Early Childhood.JAACAP open · 2024Article
- Responding to joint attention as a developmental catalyst: Longitudinal associations with language and social responsiveness.Infancy : the official journal of the International Society on Infant Studies · 2023Article
- The characteristics and factors of the internalizing and externalizing behaviours of children at high risk for autism spectrum disorder.BMC psychiatry · 2021Article
- Distributional Properties and Criterion Validity of a Shortened Version of the Social Responsiveness Scale: Results from the ECHO Program and Implications for Social Communication Research.Journal of autism and developmental disorders · 2021Article
- Attend Less, Fear More: Elevated Distress to Social Threat in Toddlers With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2021Article
- Genetic architecture of reciprocal social behavior in toddlers: Implications for heterogeneity in the early origins of autism spectrum disorder.Development and psychopathology · 2020Article
- Examining criterion-oriented validity of the Repetitive Behavior Scales for Early Childhood (RBS-EC) and the Video-Referenced Rating of Reciprocal Social Behavior (vrRSB).Development and psychopathology · 2020Article
- Quantitative trait variation in ASD probands and toddler sibling outcomes at 24 months.Journal of neurodevelopmental disorders · 2020Article
- Neuropsychiatric "Comorbidity" as Causal Influence in Autism.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Review
- Accelerating Motor Skill Acquisition for Bicycle Riding in Children with ASD: A Pilot Study.Journal of autism and developmental disorders · 2020Article
- Behavioral predictors of autism recurrence are genetically independent and influence social reciprocity: evidence that polygenic ASD risk is mediated by separable elements of developmental liability.Translational psychiatry · 2019Article
- Autism-Related Variation in Reciprocal Social Behavior: A Longitudinal Study.Child development · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Previous research has suggested that behavioral comorbidity is the rule rather than the exception in autism. The present study aimed to trace the respective origins of autistic and general psychopathologic traits-and their association-to infancy. Measurements of autistic traits and early liability for general psychopathology were assessed in 314 twins at 18 months, ascertained from the general population using birth records. 222 twins were re-evaluated at 36 months. Standardized ratings of variation in social communication at 18 months were highly heritable and strongly predicted autistic trait scores at 36 months. These early indices of autistic liability were independent from contemporaneous ratings of behavior problems on the Brief Infant-Toddler Social and Emotional Assessment (which were substantially environmentally-influenced), and did not meaningfully predict internalizing or externalizing scores on the Achenbach Scales of Empirically Based Assessment at 36 months. In this general population infant twin study, variation in social communication was independent from variation in other domains of general psychopathology, and exhibited a distinct genetic structure. The commonly-observed comorbidity of specific psychiatric syndromes with autism may arise from subsequent interactions between autistic liability and independent susceptibilities to other psychopathologic traits, suggesting opportunities for preventive amelioration of outcomes of these interactions over the course of development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.